Abstract
Measurement of sulfobromophthalein (BSP) retention in rabbits was shown to be a simple laboratory test for estimating the effects of anabolic steroids on hepatic excretory function. Non-17α-alkylated androgen-anabolic steroids failed to alter serum BSP levels, whereas 17α-alkylated anabolic steroids caused increased BSP retention when these steroids were given orally to rabbits at 10 and 20 mg/kg of body weight daily for 4 days. The magnitude of effects on BSP retention in the rabbit varied among the various l7α-alkylated steroids and did not appear to be related to myotrophic or androgenic activities, although some correlation was apparent with nitrogen-retaining activity in rats. Several published clinical reports indicated that the relative effects of 17α-alkylated anabolic steroids on BSP retention in human patients were similar to those effects observed in rabbits.
Footnotes
- Accepted August 24, 1965.
- The Williams & Wilkins Comapny
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