Abstract
The microsomal O-demethylation of p- nitroanisole to p-nitrophenol can be stimulated by pretreatment of rats with phenobarbital and other drugs. Normal and induced microsomal O-demethylases have the same overall substrate constants. Inhibition of the stimulated enzyme by the microsome inhibitor SKF 525-A shows the same kinetic characteristics as does the control demethylase, namely noncompetitive inhibition. Available evidence may suggest the identity of original and induced O-demethylase protein.
Footnotes
- Accepted July 1, 1964.
- The Williams & Wilkins Comapny
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