Abstract
Graphical analysis of the kinetics of demethylations of codeine and dextromethorphan suggests that there exist in the rat liver different enzymes which are involved in the N- and O-demethylations of these drugs. Experimental evidence is presented for the formation of codeine from morphine in vito and in vitro.
Footnotes
- Received February 8, 1963.
- Accepted December 30, 1963.
- The Williams & Wilkins Company
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