Abstract
Chlorothiazide in dilute solution was administered by constant-speed infusion into one renal artery in each of thirteen dogs. In all dogs there occurred an increase in the excretory rates of chloride, sodium and water with a lesser increase in the excretory rate of potassium. In two dogs the response was limited to the kidney being infused. In the remaining dogs, the response was bilateral but greater in the infused than the control kidney.
It is concluded that chiorothiazide acts directly at an intrarenal site to exert its excretory effects. Since renal blood flow and glomerular filtration rate did not change, this site must be tubular in origin.
Footnotes
- Received May 15, 1961.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.