Abstract
A correlation is made between aqueous-benzene partition coefficients of a series of substituted phenylboronic acids and tumor/brain ratios of these compounds in mice having subcutaneously transplanted gliomas. Those substances which concentrate preferentially in the benzene phase invariably penetrated normal brain more readily than tumor and were quite toxic to the CNS. The converse proposition, however, is not always true but compounds which did give good tumor/brain ratios were only found in the hydrophilic group. In general it would appear that lipid solubility of a compound is an important factor but certainly not the only one in determining the penetration of the brain.
Footnotes
- Received November 20, 1959.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.