Abstract
A method for detecting compounds with diuretic activity in the rat by sequential analysis is presented. Two sequential probability ratio procedures based on 0-5-hour and 0-24-hour urine volumes are described.
Of the standard diuretics which were tested, acetazolamide, amisometradine, chlorothiazide, chlormerodrin, hydrochlorothiazide, meralluride and theophylline were accepted. Urea was rejected.
The reduced amount of experimentation required by sequential testing as compared to conventional statistical testing is discussed.
Footnotes
- Received September 25, 1959.
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