Abstract
Quantitative electroencephalographic studies of cortical electrogenesis have been performed on waking, unrestrained rabbits.
Deanol (5 mg/kg, i.v.) produced, after a 30-minute latency period, a marked and longlasting increase of the voltage output. The EEG pattern was of hypersynchronization but the behavior of the animals was of overexcitation.
Choline (5 mg/kg, i.v.) did not exert any discernible effect but approximately doubled the latency period for the onset of action of deanol.
Atropine (1 mg/kg, i.v.) produced a transient depression of the effect of deanol.
Footnotes
- Received October 2, 1959.
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