Abstract
The effect of meralluride was studied on a group of 5 renal tubular enzyme systems; succinic dehydrigenase, diphosphopyridine nucleotide diaphorase, triphosphopyridine nucleotide diaphorase, glucose-6-phosphatase, and beta-glyeeryl-phosphatase. Reproducible patterns of inhibition or change in the distribution of enzymatic a ctivity were produced by varying dosages and periods of exposure. The suceptibility to change was strikingly similar in all 5 members of the group. In no instance was enzymatic activity modified without definite mercurial nephropathy being present on standard hematoxylin-cosin sections. The significance of these findings was discussed particularly in regard to the purported role of succinie dehydrogenase in mercurial pharmacology.
Footnotes
- Received July 28, 1959.
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