Abstract
The acute and chronic effects of amphetamine on locomotor activity, food intake, and weight gain in the rat are not decreased by the absence of a normally functioning thyroid gland. A significant polydipsia is seen on repeated administration of 20 mg/kg of amphetamine daily in normal rats, but not in hypothyroid rats. The development of tolerance to the appetite and weight suppressing effects of amphetamine is not paralleled by a development of tolerance to the effects on motor activity or water intake. Development of tolerance to the effects of amphetamine measured in these experiments is not affected by the absence of normal thyroid function.
Footnotes
- Received July 24, 1959.
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