Abstract
In the anesthetized dog, N-(2-endobicyclo- (2,2,1)-heptane)-diethylaminoacetamide hydrochloride (ERL-239) administered intravenously resulted in an increase of coronary blood flow. This increase occurred with doses which left the arterial blood pressure unchanged, with doses which lowered the arterial blood pressure only slightly and with doses which lowered the arterial blood pressure markedly. Cardiac output and work remained unchanged or decreased, cardiac oxygen consumption increased except with very large doses of the drug and cardiac efficiency always decreased.
Footnotes
- Received December 8, 1958.
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