Abstract
The effects of changes in acid-base balance on mersalyl- and mercury bichloride-induced diuresis and renal cellular protein-bound sulfhydryl changes have been determined in rats and dogs. In dogs alkalosis decreases mersalyl-induced sulfhydryl changes and diuresis when compared with acidotic animals. Changes in acid-basebalance do not influence mercury bichlorideinduced renal cellular sulfhydryl changes in the terminal part of the proximal tubule although alkalosis depresses mercury bichloride-induced diuresis as compared to acidotic dogs. The results are compatible with the interpretation that with the organic mercurial diuretics a splitting of the carbon-mercury bond may be operative; however, other factors such as electrolyte load are also important in determining the extent of a mercurial diuresis.
Footnotes
- Received November 1, 1958.
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