Abstract
The oxidative deamination of mescaline by various tissue preparations from 9 vertebrate species was investigated. The mescaline oxidase of rabbit liver was found to be present in the mitochondrial and microsomal fractions of the cell. The inhibitor pattern for the rabbit liver enzyme resembled that characterizing a typical diamine oxidase (DO). Similar results were obtained for the oxidation of mescaline by a partially purified hog kidney DO (histaminase) and for sheep plasma spermine oxidase. These 3 enzymes are classified as belonging to the group of semicarbazide-sensitive diamine oxidases. The experimental evidence for the degradation of mescaline by particulate preparations from hog kidney and liver, and mouse liver, implicates the action of a semicarbazide-resistant monoamine oxidase in these species.
Footnotes
- Received July 7, 1958.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|