Abstract
The results of an investigation concerning the effect of levallorphan on the respiration of rabbits given morphine have been presented. Depending on the relative and absolute doses involved, levallorphan was found to antagonize, further depress, or stimulate the respiration of morphine-treated animals. The results have been interpreted on the basis of competition for receptor sites between two pharmacologically similar agents in which the less potent agent has the greater receptor affinity.
Footnotes
- Received July 5, 1955.
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