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Journal of Pharmacology and Experimental Therapeutics

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Fast Forward

JPET Fast Forward contains papers in manuscript form that have been accepted and published in JPET but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

January 19, 2021

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    Rapid throughput concentration-response analysis of human taste discrimination
    R. Kyle Palmer, Mariah M Stewart and John Talley
    Journal of Pharmacology and Experimental Therapeutics January 19, 2021, JPET-AR-2020-000373; DOI: https://doi.org/10.1124/jpet.120.000373
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    Improved inhibitory and ADMET properties of blebbistatin derivatives indicate that blebbistatin scaffold is ideal for drug development targeting myosin-2
    Máté Gyimesi, Anna Á. Rauscher, Sharad Kumar Suthar, Kamirán Á. Hamow, Kinga Oravecz, István Lőrincz, Zsolt Borhegyi, Máté T. Déri, Ádám F. Kiss, Katalin Monostory, Pál Tamás Szabó, Suman Nag, Ivan Tomasic, Jacob Krans, Patrick J. Tierney, Mihály Kovács, László Kornya and András Málnási-Csizmadia
    Journal of Pharmacology and Experimental Therapeutics January 19, 2021, JPET-AR-2020-000167; DOI: https://doi.org/10.1124/jpet.120.000167

January 13, 2021

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    Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal NMDA Receptors,LTP and Learning
    Yukitoshi Izumi, Steven J. Mennerick, James J Doherty and Charles Zorumski
    Journal of Pharmacology and Experimental Therapeutics January 13, 2021, JPET-AR-2020-000376; DOI: https://doi.org/10.1124/jpet.120.000376
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    Enhancement of opioid antinociception by nicotinic ligands
    Fernando Barreto de Moura and Jack Bergman
    Journal of Pharmacology and Experimental Therapeutics January 13, 2021, JPET-AR-2020-000423; DOI: https://doi.org/10.1124/jpet.120.000423

January 11, 2021

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    Safety, Pharmacokinetic and Pharmacodynamic Evaluation of a 2'-MOE Antisense Oligonucleotide-GalNAc3 Conjugate that Targets the Human Transmembrane Protease Serine 6 (TMPRSS6)
    Thomas A Zanardi, Birgit Korbmacher, Laura Boone, Jeffrey A Engelhardt, Yanfeng Wang, Sebastien Burel, Bobby Prill, Mariam Aghajan, Shuling Guo and Scott P Henry
    Journal of Pharmacology and Experimental Therapeutics January 11, 2021, JPET-AR-2020-000222; DOI: https://doi.org/10.1124/jpet.120.000222
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    Methocinnamox (MCAM) reverses and prevents fentanyl-induced ventilatory depression in rats
    Victor M Jimenez, Gabriel Castaneda and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics January 11, 2021, JPET-AR-2020-000387; DOI: https://doi.org/10.1124/jpet.120.000387
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    Pharmacological activation of neuronal Kv7/KCNQ/M-current by a novel channel opener SCR2682 for alleviation of chronic pain
    Jing Wang, Yani Liu, Fang Hu, Jiuyong Yang, Xiaoyu Guo, Xingming Hou, Chuanxia Ju and Kewei Wang
    Journal of Pharmacology and Experimental Therapeutics January 11, 2021, JPET-AR-2020-000357; DOI: https://doi.org/10.1124/jpet.120.000357

January 07, 2021

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    Knockout of γ-Adducin Promotes NG-Nitro-L-Arginine-Methyl-Ester (L-NAME)-Induced Hypertensive Renal Injury
    Letao Fan, Wenjun Gao, Yedan Liu, Joshua R. Jefferson, Fan Fan and Richard J. Roman
    Journal of Pharmacology and Experimental Therapeutics January 7, 2021, JPET-AR-2020-000408; DOI: https://doi.org/10.1124/jpet.120.000408
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    Acetate, a Short-Chain Fatty Acid, Acutely Lowers Heart Rate and Cardiac Contractility along with Blood Pressure
    Brian G Poll, Jiaojiao Xu, Seungho Jun, Jason Sanchez, Nathan Zaidman, Xiaojun He, Laeben Lester, Dan Berkowitz, Nazareno Paolocci, Wei Dong Gao and Jennifer Pluznick
    Journal of Pharmacology and Experimental Therapeutics January 7, 2021, JPET-AR-2020-000187; DOI: https://doi.org/10.1124/jpet.120.000187

January 04, 2021

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    Phytochemical regulation of RNA in treating inflammatory bowel disease and colon cancer: inspirations from Cell and Animal studies
    Guolin Zhang, Chi Zhang, Jia'ao Sun, Yongjian Xiong, Liang Wang and Dapeng Chen
    Journal of Pharmacology and Experimental Therapeutics January 4, 2021, JPET-COM-2020-000354; DOI: https://doi.org/10.1124/jpet.120.000354

December 31, 2020

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    Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for Mu-Opioid Receptor and Opioid-Like Behavioral Effects in Rats
    Samuel Obeng, Jenny L. Wilkerson, Francisco León, Morgan E Reeves, Luis F Restrepo, Lea R Gamez-Jimenez, Avi Patel, Anna E Pennington, Victoria A Taylor, Nicholas P Ho, Tobias Braun, John D Fortner, Morgan L Crowley, Morgan R Williamson, Victoria LC Pallares, Marco Mottinelli, Carolina Lopera-Londoño, Christopher R. McCurdy, Lance R. McMahon and Takato Hiranita
    Journal of Pharmacology and Experimental Therapeutics December 31, 2020, JPET-AR-2020-000189; DOI: https://doi.org/10.1124/jpet.120.000189
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    Novel Tocolytic Strategy: Modulating Cx43 Activity by S-Nitrosation
    Scott D. Barnett, Hazik Asif, Mitchell T. Anderson and Iain L.O. Buxton
    Journal of Pharmacology and Experimental Therapeutics December 31, 2020, JPET-AR-2020-000427; DOI: https://doi.org/10.1124/jpet.120.000427

December 29, 2020

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    Opening of intermediate conductance Ca2+-activated K+ channels in C2C12 skeletal muscle cells increases the myotube diameter via the Akt/mTOR pathway
    Yuzo Iseki, Yuko Ono, Chihiro Hibi, Shoko Tanaka, Shunya Takeshita, Yuko Maejima, Junko Kurokawa, Masahiro Murakawa, Kenju Shimomura and Kazuho Sakamoto
    Journal of Pharmacology and Experimental Therapeutics December 29, 2020, JPET-AR-2020-000290; DOI: https://doi.org/10.1124/jpet.120.000290
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    Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical TRPV4 Target Engagement Ex Vivo
    Xiaoping Xu, Navin Goyal, Melissa H Costell, Theresa Roethke, Christian H James, Kevin S Thorneloe, Jaclyn R Patterson, Patrick Stoy, Krista Goodman, Dennis L Sprecher and David J Behm
    Journal of Pharmacology and Experimental Therapeutics December 29, 2020, JPET-AR-2020-000307; DOI: https://doi.org/10.1124/jpet.120.000307

December 23, 2020

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    Self-administration of cotinine in Wistar rats: comparisons to nicotine
    Zheng-Ming Ding, Yong Gao, Alena Sentir and Xiaoying Tan
    Journal of Pharmacology and Experimental Therapeutics December 23, 2020, JPET-AR-2020-000367; DOI: https://doi.org/10.1124/jpet.120.000367

December 22, 2020

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    Manipulating Pharmacodynamic Efficacy with Agonist + Antagonist Mixtures:In Vitro and In Vivo Studies with Opioids and Cannabinoids
    Dana E. Selley, Matthew L. Banks, Clare M Diester, Abdul M Jali, Luke P. Legakis, Edna J Santos and S. Stevens Negus
    Journal of Pharmacology and Experimental Therapeutics December 22, 2020, JPET-AR-2020-000349; DOI: https://doi.org/10.1124/jpet.120.000349

December 18, 2020

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    RNAi targeting liver Angiopoietin-like protein 3 protects from nephrotic syndrome in a rat model via amelioration of pathologic hypertriglyceridemia
    Yitong Zhao, Masaki Goto, Nosratola D Vaziri, Mahyar Khazaeli, Han Liu, Nazli Farahanchi, Elham Khanifar, Ted Farzaneh, Patrick A Haslett, Hamid Moradi and Mangala M Soundarapandian
    Journal of Pharmacology and Experimental Therapeutics December 18, 2020, JPET-AR-2020-000257; DOI: https://doi.org/10.1124/jpet.120.000257

December 17, 2020

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    Different anti-oxidative and anti-apoptotic effects of piceatannol and resveratrol.
    Ryusuke Hosoda, Hiroki Hamada, Daisuke Uesugi, Naotoshi Iwahara, Iyori Nojima, Yoshiyuki Horio and Atsushi Kuno
    Journal of Pharmacology and Experimental Therapeutics December 17, 2020, JPET-AR-2020-000096; DOI: https://doi.org/10.1124/jpet.120.000096

December 16, 2020

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    Discovery of M5049: A Novel Selective TLR7/8 Inhibitor for Treatment of Autoimmunity
    Jaromir Vlach, Andrew T Bender, Melinda Przetak, Albertina Pereira, Aditee Deshpande, Theresa Johnson, Sonja Reissig, Evgeni Tzvetkov, Djordje Musil, Noune Tahmassian-Morse, Phillip Haselmayer, Simone Favre-Zimmerli, Shinji L Okitsu, Robert L. Walsky and Brian Sherer
    Journal of Pharmacology and Experimental Therapeutics December 16, 2020, JPET-AR-2020-000275; DOI: https://doi.org/10.1124/jpet.120.000275

December 15, 2020

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    A phenyl pyrrolidine derivative reveals a dual inhibition mechanism of myocardial mitochondrial permeability transition pore, which is limited by its myocardial distribution.
    mathieu panel, Abdelhakim Ahmed-Belkacem, Isaac Ruiz, jean-françois Guichou, jean-michel pawlotsky, bijan ghaleh and didier morin
    Journal of Pharmacology and Experimental Therapeutics December 15, 2020, JPET-AR-2020-000359; DOI: https://doi.org/10.1124/jpet.120.000359

December 14, 2020

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    β3-adrenergic receptor agonist prevents diastolic dysfunction in an angiotensin II-induced cardiomyopathy mouse model
    Masataka Kamiya, Kuniya Asai, Yasuhiro Maejima, Akihiro Shirakabe, Koji Murai, Satsuki Noma, Hidenori Komiyama, Naoki Sato and Wataru Shimizu
    Journal of Pharmacology and Experimental Therapeutics December 14, 2020, JPET-AR-2020-000140; DOI: https://doi.org/10.1124/jpet.120.000140
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    Activation of the G protein-coupled estrogen receptor prevented the development of acute colitis by protecting the crypt cell
    Qian Wang, Zhao Li, Kaixuan Liu, Jianbo Liu, Shiquan Chai, Guanyu Chen, Shuyu Wen, Tian Ming, Jiayi Wang, Yuntao Ma, Honghui Zeng, Chuanyong Liu and Bing Xue
    Journal of Pharmacology and Experimental Therapeutics December 14, 2020, JPET-AR-2020-000216; DOI: https://doi.org/10.1124/jpet.120.000216
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    Downregulation of the αvβ6 integrin via RGD engagement is affinity- and time-dependent.
    James Alexander Roper, Alex L Wilkinson, Elaine Gower and Robert J Slack
    Journal of Pharmacology and Experimental Therapeutics December 14, 2020, JPET-AR-2020-000379; DOI: https://doi.org/10.1124/jpet.120.000379

December 11, 2020

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    A Network Pharmacology-Based Analysis of the Protective Mechanism of Miao Medicine Xuemaitong Capsule against Secondary Brain Damage in the Ischemic area Surrounding Intracerebral Hemorrhage
    Bo Zhang, Zhengyan Zeng and Haijun Wu
    Journal of Pharmacology and Experimental Therapeutics December 11, 2020, JPET-AR-2020-000083; DOI: https://doi.org/10.1124/jpet.120.000083

December 10, 2020

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    Distinct uptake kinetics of Alzheimer's disease amyloid beta 40 and 42 at the blood-brain barrier endothelium
    Nidhi Sharda, Kristen M Ahlschwede, Geoffry L Curran, Val J Lowe and Karunya K. Kandimalla
    Journal of Pharmacology and Experimental Therapeutics December 10, 2020, JPET-AR-2020-000086; DOI: https://doi.org/10.1124/jpet.120.000086

December 08, 2020

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    Pharmacology and mechanism of action of HSK16149, a selective ligand of α2δ subunit of voltage-gated calcium channel with analgesic activity in animal models of chronic pain
    Xiaoli Gou, Xiaojuan Yu, Dongdong Bai, Bowei Tan, Pingfeng Cao, Meilin Qian, Xiaoxiao Zheng, Lei Chen, Zongjun Shi, Yao Li, Fei Ye, Yong Liang and Jia Ni
    Journal of Pharmacology and Experimental Therapeutics December 8, 2020, JPET-AR-2020-000315; DOI: https://doi.org/10.1124/jpet.120.000315

December 07, 2020

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    Calculation of an Apical Efflux Ratio from P-glycoprotein (P-gp) In Vitro Transport Experiments Shows an Improved Correlation with In Vivo CSF Measurements in Rats - Impact on P-gp Screening and Compound Optimization
    Holger Fischer, Claudia Senn, Mohammed Ullah, Carina Cantrill, Franz Schuler and Li Yu
    Journal of Pharmacology and Experimental Therapeutics December 7, 2020, JPET-AR-2020-000158; DOI: https://doi.org/10.1124/jpet.120.000158

December 04, 2020

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    Physiologically-Based Pharmacokinetics of Lysosomotropic Chloroquine in Rat and Man
    Xin Liu and William J Jusko
    Journal of Pharmacology and Experimental Therapeutics December 4, 2020, JPET-AR-2020-000385; DOI: https://doi.org/10.1124/jpet.120.000385
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    Increased levels of renal lysophosphatidic acid in rodent models with renal disease.
    Takashi Hirata, Stanley V. Smith, Teisuke Takahashi, Noriyuki Miyata and Richard J. Roman
    Journal of Pharmacology and Experimental Therapeutics December 4, 2020, JPET-AR-2020-000353; DOI: https://doi.org/10.1124/jpet.120.000353

November 30, 2020

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    Sphingosine 1-phosphate Receptor Modulator ONO-4641 Regulates Trafficking of T Lymphocytes and Hematopoietic Stem Cells and Alleviates Immune-Mediated Aplastic Anemia in a Mouse Model
    Takaki Komiya, Masashi Goda, Hiroki Shioya and Seishi Katsumata
    Journal of Pharmacology and Experimental Therapeutics November 30, 2020, JPET-AR-2020-000277; DOI: https://doi.org/10.1124/jpet.120.000277

November 25, 2020

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    Fingolimod Phosphate (FTY720-P) Activates Protein Phosphatase 2A in Human Monocytes and Inhibits Monosodium Urate Crystal-Induced IL-1β Production
    Marwa M Qadri, Sandy ElSayed and Khaled A Elsaid
    Journal of Pharmacology and Experimental Therapeutics November 25, 2020, JPET-AR-2020-000321; DOI: https://doi.org/10.1124/jpet.120.000321

November 17, 2020

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    Pharmacological Actions of Carbamate Insecticides at Mammalian Melatonin Receptors
    Grant C Glatfelter, Anthony J Jones, Rajendram V Rajnarayanan and Margarita L Dubocovich
    Journal of Pharmacology and Experimental Therapeutics November 17, 2020, JPET-AR-2020-000065; DOI: https://doi.org/10.1124/jpet.120.000065

November 10, 2020

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    Lysosomal Biogenesis and Implications for Hydroxychloroquine Disposition
    Keagan P Collins, Sandra Witta, Jonathan Coy, Yi Pang and Daniel L. Gustafson
    Journal of Pharmacology and Experimental Therapeutics November 10, 2020, JPET-AR-2020-000309; DOI: https://doi.org/10.1124/jpet.120.000309

November 09, 2020

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    Predictors of early or delayed diastolic dysfunction after anthracycline-based or nonanthracycline chemotherapy: A pharmacological appraisal
    Giorgio Minotti, Pierantonio Menna, Massimiliano Camilli, Emanuela Salvatorelli and Giorgio Reggiardo
    Journal of Pharmacology and Experimental Therapeutics November 9, 2020, JPET-AR-2020-000323; DOI: https://doi.org/10.1124/jpet.120.000323

November 05, 2020

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    Mast cell degranulation increases mouse Mast Cell Protease 4-dependent vasopressor responses to big endothelin-1 but not Angiotensin I
    Laurence Vincent, Catherine Lapointe, Modou Lo, Hugo Gagnon, Gunnar Pejler, Shinji Takai, Robert Day and Pedro D'Orleans-Juste
    Journal of Pharmacology and Experimental Therapeutics November 5, 2020, JPET-AR-2020-000325; DOI: https://doi.org/10.1124/jpet.120.000325

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