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Journal of Pharmacology and Experimental Therapeutics

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Fast Forward

JPET Fast Forward contains papers in manuscript form that have been accepted and published in JPET but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

January 20, 2023

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    Pharmacologic activity of substituted tryptamines at 5-HT2AR, 5-HT2CR, 5-HT1AR, and SERT
    Laura B Kozell, Amy J. Eshleman, Tracy L Swanson, Shelley H Bloom, Katherine M Wolfrum, Jennifer L Schmachtenberg, Randall J Olson, Aaron J. Janowsky and Atheir I Abbas
    Journal of Pharmacology and Experimental Therapeutics January 20, 2023, JPET-AR-2022-001454; DOI: https://doi.org/10.1124/jpet.122.001454
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    Cannabinoid tolerance in S426A/S430A x beta-arrestin 2 knock-out double mutant mice
    Mary K Piscura, Diana E Sepulveda, Malabika Maulik, Josee Guindon, Angela N Henderson-Redmond and Daniel J. Morgan
    Journal of Pharmacology and Experimental Therapeutics January 20, 2023, JPET-AR-2022-001367; DOI: https://doi.org/10.1124/jpet.122.001367
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    Neurochemical and cardiovascular effects of 4-chloro ring-substituted synthetic cathinones in rats
    Michael R Chojnacki, Eric B. Thorndike, John S. Partilla, Kenner C. Rice, Charles W. Schindler and Michael H Baumann
    Journal of Pharmacology and Experimental Therapeutics January 20, 2023, JPET-AR-2022-001478; DOI: https://doi.org/10.1124/jpet.122.001478

January 17, 2023

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    THE EFFECTS OF THE DOPAMINE TRANSPORTER LIGANDS JJC8-088 AND JJC8-091 ON COCAINE VS. FOOD CHOICE IN RHESUS MONKEYS
    Omeed Rahimi, Jianjing Cao, Jenny Lam, Steven R. Childers, Rana Rais, Linda J. Porrino, Amy Hauck Newman and Michael A. Nader
    Journal of Pharmacology and Experimental Therapeutics January 17, 2023, JPET-AR-2022-001363; DOI: https://doi.org/10.1124/jpet.122.001363

January 12, 2023

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    Identification of glucose transport modulators in vitro and method for their deep learning neural network behavioral evaluation in Glut1 deficient mice
    Gauri Kathote, Qian Ma, Gustavo Angulo, Hong Chen, Vikram Jakkamsetti, Aksharkumar Dobariya, Levi B. Good, Bruce Posner, Jason Y. Park and Juan M. Pascual
    Journal of Pharmacology and Experimental Therapeutics January 12, 2023, JPET-AR-2022-001428; DOI: https://doi.org/10.1124/jpet.122.001428
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    Ocular Administration of Palonosetron in the Prevention of Cisplatin-Induced Nausea and Vomiting
    Jouko Levijoki, Lasse Saloranta, Johanna Tuunainen, Janne Kaskinoro, Sari Pappinen, Sandra Nourry, Anne-Marie Betat, Anne Maurin, Maarit Pakarinen, Sari Häkkinen, Johanna Tervapuro, Hertta Pihlasvaara, Christophe Drieu La Rochelle and Heikki Joensuu
    Journal of Pharmacology and Experimental Therapeutics January 12, 2023, JPET-AR-2022-001444; DOI: https://doi.org/10.1124/jpet.122.001444

January 11, 2023

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    Initial pharmacological characterization of a major hydroxy metabolite of PF-5190457: inverse agonist activity of PF-6870961 at the ghrelin receptor
    Sara L. Deschaine, Morten A. Hedegaard, Claire L. Pince, Mehdi Farokhnia, Jacob E Moose, Ingrid A Stock, Sravani Adusumalli, Fatemeh Akhlaghi, James L. Hougland, Agnieszka Sulima, Kenner C. Rice, George F. Koob, Leandro Vendruscolo, Birgitte Holst and Lorenzo Leggio
    Journal of Pharmacology and Experimental Therapeutics January 11, 2023, JPET-AR-2022-001393; DOI: https://doi.org/10.1124/jpet.122.001393
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    Pharmacokinetic/Pharmacodynamic Modeling of Dexamethasone Anti-Inflammatory and Immunomodulatory Effects in LPS-Challenged Rats: A Model for Cytokine Release Syndrome
    Artur Świerczek and William J Jusko
    Journal of Pharmacology and Experimental Therapeutics January 11, 2023, JPET-AR-2022-001477; DOI: https://doi.org/10.1124/jpet.122.001477

January 10, 2023

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    Disruption of ovarian cancer STAT3 and p38 signaling with a small molecule inhibitor of PTP4A3 phosphatase
    John S. Lazo, Kelly N. Isbell, Sai Ashish Vasa, Danielle C. Llaneza, Ettore J. Rastelli, Peter Wipf and Elizabeth R. Sharlow
    Journal of Pharmacology and Experimental Therapeutics January 10, 2023, JPET-AR-2022-001401; DOI: https://doi.org/10.1124/jpet.122.001401
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    MDPV high-responder phenotype as a tool to evaluate candidate medications for stimulant use disorder
    Michelle R. Doyle, Lindsey N Peng, Jianjing Cao, Kenner C. Rice, Amy Hauck Newman and Gregory T. Collins
    Journal of Pharmacology and Experimental Therapeutics January 10, 2023, JPET-AR-2022-001419; DOI: https://doi.org/10.1124/jpet.122.001419

December 27, 2022

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    Attenuation of the positive-reinforcing effects of ultra-potent fentanyl analogs, along with those of fentanyl and heroin, during daily treatment with methocinnamox (MCAM) in rhesus monkeys
    Lisa R. Gerak and Charles P. France
    Journal of Pharmacology and Experimental Therapeutics December 27, 2022, JPET-AR-2022-001267; DOI: https://doi.org/10.1124/jpet.122.001267

December 06, 2022

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    The Novel, Clinical Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease
    Glenn A. Reinhart, Paul C. Harrison, Kathleen Lincoln, Hongxing Chen, Peng Sun, Jon Hill, Hu Sheng Qian, Mark McHugh, Holly Clifford, Khing Jow Ng, Hong Wang, Danielle Fowler, Kristina K. Gueneva-Boucheva, Todd Bosanac, Diane Wong, Ryan M. Fryer, Chris Sarko, Carine M Boustany-Kari and Steven S. Pullen
    Journal of Pharmacology and Experimental Therapeutics December 6, 2022, JPET-AR-2022-001423; DOI: https://doi.org/10.1124/jpet.122.001423

December 05, 2022

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    Neutralizing MIP3a reduces renal immune cell infiltration and progressive renal injury in young obese Dahl salt-sensitive rats
    Ubong S Ekperikpe, Bibek Poudel, Corbin A Shields, Sautan Mandal, Denise C Cornelius and Jan M Williams
    Journal of Pharmacology and Experimental Therapeutics December 5, 2022, JPET-AR-2022-001298; DOI: https://doi.org/10.1124/jpet.122.001298

December 02, 2022

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    Protein 14-3-3 Influences the Response of the Cardiac Sodium Channel Nav1.5 to Anti-Arrhythmic Drugs
    Yang Zheng and Isabelle Deschenes
    Journal of Pharmacology and Experimental Therapeutics December 2, 2022, JPET-AR-2022-001407; DOI: https://doi.org/10.1124/jpet.122.001407

December 01, 2022

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    Delta opioid receptor-mediated antidepressant-like effects of diprenorphine in mice
    Keith M Olson, Todd M. Hillhouse, Gwendolyn E Burgess, Joshua L. West, James E Hallahan, Isaac J Dripps, Allison G Ladetto, Kenner C. Rice, Emily M. Jutkiewicz and John R. Traynor
    Journal of Pharmacology and Experimental Therapeutics December 1, 2022, JPET-AR-2022-001182; DOI: https://doi.org/10.1124/jpet.122.001182

November 23, 2022

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    The effects of dual GLP-1/GCG receptor agonists with different receptor selectivity in mouse models of obesity and NASH
    Ashref Kayed, Simone Anna Melander, Suheb Khan, Kim Vietz Andreassen, Morten Asser Karsdal and Kim Henriksen
    Journal of Pharmacology and Experimental Therapeutics November 23, 2022, JPET-AR-2022-001440; DOI: https://doi.org/10.1124/jpet.122.001440

November 15, 2022

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    Insulin Suppresses Ubiquitination via the Deubiquitinating Enzyme USP14, Independent of Proteasome Activity in H4IIEC3 Hepatocytes
    Kyoko Kamoshita, Kiyo-Aki Ishii, Yumiko Tahira, Akihiro Kikuchi, Halimulati Abuduwaili, Natsumi Tajima-Shirasaki, Qifang Li, Hiroaki Takayama, Kunio Matsumoto and Toshinari Takamura
    Journal of Pharmacology and Experimental Therapeutics November 15, 2022, JPET-AR-2022-001088; DOI: https://doi.org/10.1124/jpet.122.001088

October 14, 2022

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    Pharmacodynamic and Antitumor Activity of BI 836880, a Dual VEGF and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition
    Irmgard Hofmann, Anke Baum, Marco H. Hofmann, Francesca Trapani, Claudia Reichel-Voda, Diane Ehrensperger, Martin Aichinger, Florian Ebner, Nicole Budano, Norbert Schweifer, Martina Sykora, Erik Depla, Joachim Boucneau, Andreas Gschwind, Norbert Kraut, Frank Hilberg and Klaus-Peter Künkele
    Journal of Pharmacology and Experimental Therapeutics October 14, 2022, JPET-AR-2022-001255; DOI: https://doi.org/10.1124/jpet.122.001255

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