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Journal of Pharmacology and Experimental Therapeutics

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Fast Forward

JPET Fast Forward contains papers in manuscript form that have been accepted and published in JPET but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Behavioral Pharmacology

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    Novel Antimuscarinic Antidepressant-like Compounds with Reduced Effects on Cognition
    Chad Richard Johnson, Brian D. Kangas, Emily M. Jutkiewicz, Gail Winger, Jack Bergman, Andrew Coop and James H. Woods
    Journal of Pharmacology and Experimental Therapeutics March 15, 2021, JPET-AR-2020-000337; DOI: https://doi.org/10.1124/jpet.120.000337
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    Behavioral Battery for Testing Candidate Analgesics in Mice. I. Validation with Positive and Negative Controls
    Clare M Diester, Edna J Santos, Megan Jo Moerke and S. Stevens Negus
    Journal of Pharmacology and Experimental Therapeutics February 23, 2021, JPET-AR-2020-000464; DOI: https://doi.org/10.1124/jpet.120.000464
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    Behavioral Battery for Testing Candidate Analgesics in Mice. II. Effects of Endocannabinoid Catabolic Enzyme Inhibitors and ∆9-Tetrahydrocannabinol
    Clare M Diester, Aron H. Lichtman and S. Stevens Negus
    Journal of Pharmacology and Experimental Therapeutics February 23, 2021, JPET-AR-2021-000497; DOI: https://doi.org/10.1124/jpet.121.000497

Cardiovascular

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    Rosuvastatin inhibits the apoptosis of platelet-derived growth factor-stimulated vascular smooth muscle cells by inhibiting p38 via autophagy
    Jun-Hwan Jo, Hyun-Soo Park, Do-Hyung Lee, Joo-Hui Han, Kyung-Sun Heo and Chang-Seon Myung
    Journal of Pharmacology and Experimental Therapeutics April 12, 2021, JPET-AR-2021-000539; DOI: https://doi.org/10.1124/jpet.121.000539
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    Inhibition of G6PD activity attenuates right ventricle pressure and hypertrophy elicited by VEGFR inhibitor + hypoxia
    Atsushi Kitagawa, Christina Jacob, Allan Jordan, Ian Waddell, Ivan F Mcmurtry and Sachin A Gupte
    Journal of Pharmacology and Experimental Therapeutics March 23, 2021, JPET-AR-2020-000166; DOI: https://doi.org/10.1124/jpet.120.000166
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    Chronic Ca2+/Calmodulin-Dependent Protein Kinase II Inhibition Rescues Advanced Heart Failure
    Yixi Liu, Qun Shao, Heng-Jie Cheng, Tiankai Li, Xiaowei Zhang, Michael F Callahan, David Herrington, Dalane Kitzman, David Zhao and Che-Ping Cheng
    Journal of Pharmacology and Experimental Therapeutics March 15, 2021, JPET-AR-2020-000361; DOI: https://doi.org/10.1124/jpet.120.000361
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    Therapeutic assessment of combination therapy with a neprilysin inhibitor and angiotensin type 1 receptor antagonist on angiotensin II-induced atherosclerosis, abdominal aortic aneurysms, and hypertension
    Yasir Alsiraj, Sean Thatcher, Ching Ling Liang, Heba Ali, Mark Ensor and Lisa Cassis
    Journal of Pharmacology and Experimental Therapeutics March 11, 2021, JPET-AR-2021-000525; DOI: https://doi.org/10.1124/jpet.121.000525
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    COVID-19 drugs chloroquine and hydroxychloroquine, but not azithromycin and remdesivir, block hERG potassium channels
    Mark Szendrey, Jun Guo, Wentao Li, Tonghua Yang and Shetuan Zhang
    Journal of Pharmacology and Experimental Therapeutics March 5, 2021, JPET-AR-2020-000484; DOI: https://doi.org/10.1124/jpet.120.000484

Cellular and Molecular

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    Poly (ADP-ribose) polymerase inhibitors for arsenic trioxide-resistant acute promyelocytic leukemia: synergistic in vitro antitumor effects with hypomethylating agents or high-dose vitamin C
    Manuela Giansanti, Antonio De Gabrieli, Salvatore Pasquale Prete, Tiziana Ottone, Maria Domenica Divona, Terry Karimi, Fabio Ciccarone, Maria Teresa Voso, Grazia Graziani and Isabella Faraoni
    Journal of Pharmacology and Experimental Therapeutics April 5, 2021, JPET-AR-2021-000537; DOI: https://doi.org/10.1124/jpet.121.000537
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    Circ-KRT6C promotes malignant progression and immune evasion of colorectal cancer through miR-485-3p/PDL1 axis
    Zhipeng Jiang, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang and Shuang Chen
    Journal of Pharmacology and Experimental Therapeutics March 26, 2021, JPET-AR-2021-000518; DOI: https://doi.org/10.1124/jpet.121.000518

Chemotherapy, Antibiotics, and Gene Therapy

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    Synergistic pharmacodynamic effects of gemcitabine and fibroblast growth factor receptor inhibitors on pancreatic cancer cell cycle kinetics and proliferation
    Qingxiang Lin, Zhicheng Qian, William J Jusko, Donald E. Mager, Wen Wee Ma and Robert M. Straubinger
    Journal of Pharmacology and Experimental Therapeutics March 22, 2021, JPET-AR-2020-000412; DOI: https://doi.org/10.1124/jpet.120.000412

Drug Discovery and Translational Medicine

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    AM833 is a novel agonist of calcitonin family G protein-coupled receptors: pharmacological comparison to six selective and non-selective agonists
    Madeleine M Fletcher, Peter Keov, Tin T Truong, Grace Mennen, Caroline A Hick, Peishen Zhao, Sebastian G.B. Furness, Thomas Kruse, Trine R Clausen, Denise Wootten and Patrick M. Sexton
    Journal of Pharmacology and Experimental Therapeutics March 16, 2021, JPET-AR-2021-000567; DOI: https://doi.org/10.1124/jpet.121.000567
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    A novel integrated pharmacokinetic-pharmacodynamic model to evaluate combination therapy and determine in vivo synergism
    Young Hee Choi, Chao Zhang, Zhenzhen Liu, Mei-Juan Tu, Ai-Xi Yu and Ai-Ming Yu
    Journal of Pharmacology and Experimental Therapeutics March 12, 2021, JPET-AR-2021-000584; DOI: https://doi.org/10.1124/jpet.121.000584
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    Clostridium Butyricum Alleviates the Gut Microbiota Alteration Induced Bone Loss after Bariatric Surgery by Promoting Bone Autophagy
    Xueying Shang, Xiaolei Zhang, Cen Du, Zhuoqi Ma, Shi Jin, Na Ao, Jing Yang and Jian Du
    Journal of Pharmacology and Experimental Therapeutics March 3, 2021, JPET-AR-2020-000410; DOI: https://doi.org/10.1124/jpet.120.000410
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    SAR340835, a novel selective NCX inhibitor, improves cardiac function and restores sympathovagal balance in Heart Failure.
    Michel Pelat, Fabrice Barbe, Cyril Daveu, Laetitia Ly-Nguyen, Thomas Lartigue, Suzanne Marque, Georges Tavares, Veronique Ballet, Jean-Michel Guillon, Klaus Steinmeyer, Klaus Wirth, Heinz Gögelein, Petra Arndt, Nils Rackelmann, John Weston, Patrice Bellevergue, Gary McCort, Marc Trellu, Laurence Lucats, Philippe Beauverger, Marie-Pierre Pruniaux-Harnist, Philip Janiak and Frédérique Chézalviel-Guilbert
    Journal of Pharmacology and Experimental Therapeutics February 18, 2021, JPET-AR-2020-000238; DOI: https://doi.org/10.1124/jpet.120.000238

Endocrine and Diabetes

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    Ginsenoside Ro ameliorates high fat diet-induced obesity and insulin resistance in mice via activation of the TGR5 pathway
    Lin-shan Jiang, Wei Li, Tong-xi Zhuang, Jie-jing Yu, Shuai Sun, Zheng-cai Ju, Zheng-tao Wang, Li-li Ding and Li Yang
    Journal of Pharmacology and Experimental Therapeutics April 5, 2021, JPET-AR-2020-000435; DOI: https://doi.org/10.1124/jpet.120.000435

Gastrointestinal, Hepatic, Pulmonary, and Renal

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    Increasing effects of selective 5-HT2C receptor stimulation on evoked momentary urethral closure in female rats and humans
    Izumi Kamo, Hiroshi Nagata, Gale O'Connell, Takuya Kato, Akio Imanishi, Masako Kuno, Satoshi Okanishi, Kyoko Yoshikawa and Yuya Nishiyama
    Journal of Pharmacology and Experimental Therapeutics April 9, 2021, JPET-AR-2021-000573; DOI: https://doi.org/10.1124/jpet.121.000573
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    Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters
    Michele Leuenberger, Stephanie Häusler, Vera Höhn, Adriana Euler, Bruno Stieger and Martin Lochner
    Journal of Pharmacology and Experimental Therapeutics March 29, 2021, JPET-AR-2020-000449; DOI: https://doi.org/10.1124/jpet.120.000449

Inflammation, Immunopharmacology, and Asthma

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    CANNABIDIOL ENHANCES INTESTINAL CB2 RECEPTOR EXPRESSION AND ACTIVATION INCREASING REGULATORY T CELLS AND REDUCES MURINE ACUTE GRAFT-VERSUS-HOST DISEASE WITHOUT INTERFERING WITH THE GRAFT-VERSUS-LEUKEMIA RESPONSE
    Bárbara Betônico Berg, Jaqueline Silva Soares, Isabela Ribeiro Paiva, Barbara Maximino Rezende, Milene Alvarenga Rachid, Stêfany Bruno de Assis Cau, Thiago Roberto Lima Romero, Vanessa Pinho, Mauro Martins Teixeira and Marina Gomes Miranda Castor
    Journal of Pharmacology and Experimental Therapeutics March 3, 2021, JPET-AR-2020-000479; DOI: https://doi.org/10.1124/jpet.120.000479

Neuropharmacology

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    Development of CVN424: a selective and novel GPR6 inverse agonist effective in models of Parkinson's Disease
    Nicola L Brice, Hans H Schiffer, Holger Monenschein, Victoria J Mulligan, Keith Page, Justin Powell, Xiao Xu, Toni Cheung, J Russell Burley, Huikai Sun, Louise Dickson, Sean T Murphy, Nidhi Kaushal, Steven Sheardown, Jason Lawrence, Yun Chen, Darian Bartkowski, Anne Kanta, Joseph Russo, Natalie Hosea, Lee A Dawson, Stephen H Hitchcock and Mark B Carlton
    Journal of Pharmacology and Experimental Therapeutics April 1, 2021, JPET-AR-2020-000438; DOI: https://doi.org/10.1124/jpet.120.000438
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    Brain Concentrations of Methylone and its Metabolites After Systemic Methylone Administration: Relationship to Pharmacodynamic Effects
    Nicole Centazzo, Michel R Chojnacki, Joshua S Elmore, Raider Rodriguez, Teeshavi Acosta, Masaki Suzuki, Kenner C Rice, Michael H Baumann and Marta Concheiro
    Journal of Pharmacology and Experimental Therapeutics March 30, 2021, JPET-AR-2021-000531; DOI: https://doi.org/10.1124/jpet.121.000531

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