Data Supplement

• Supplemental Figures -

  Supplemental figure 1. P2pal-18S treatment attenuates EAE disease severity.
  

  Supplemental figure 2. Flow cytometry gating strategy.
  

  Supplemental figure 3. Serum levels of multiple cytokines and chemokines in EAE mice.
  

  Supplemental figure 4. Splenocytes and macrophages express functional PAR2.
  

  Supplemental figure 5. P2pal-18S is not cytotoxic for T cells.
  

  Supplemental figure 6. P2pal-18S reduces T cell production of cytokines and chemokines in vitro.
  

  Supplemental figure 7. P2pal-18S has no effect on the production of cytokines by LPSstimulated macrophages.