Data Supplement

• Supplemental Figures -

  Figure S1. {¹H NMR} spectrum of 3-fluoro-4-aminopyridine-5-d₁ (2-d₁).
  

  Figure S2. {¹³C NMR} spectrum of 3-fluoro-4-aminopyridine-5-d₁ (2-d₁).

  Figure S3. {¹⁹F NMR} spectrum of 3-fluoro-4-aminopyridine-5-d₁ (2-d₁).

  Figure S4. {¹H NMR} spectrum of 3-fluoro-4-aminopyridine-2,6-d₂ (2-d₂).

  Figure S5. {¹³C NMR} spectrum of 3-fluoro-4-aminopyridine-2,6-d₂ (2-d₂).

  Figure S6. {¹⁹F NMR} spectrum of 3-fluoro-4-aminopyridine-2,6-d₂ (2-d₂).

  Figure S7. {¹H NMR} spectrum of 3-fluoro-4-aminopyridine-2,5,6-d₃ (2-d₃).

  Figure S8. {¹³C NMR} spectrum of 3-fluoro-4-aminopyridine-2,5,6-d₃ (2-d₃).

  Figure S9. {¹⁹F NMR} spectrum of 3-fluoro-4-aminopyridine-2,5,6-d₃ (2-d₃).

  Figure S10. {¹H NMR} spectrum of 3-fluoro-4-aminopyridine 1-oxide (9a).

  Figure S11. {¹³C NMR} spectrum of 3-fluoro-4-aminopyridine 1-oxide (9a).

  Figure S12. {¹⁹F NMR} spectrum of 3-fluoro-4-aminopyridine 1-oxide (9a).

  Figure S13. {¹H NMR} spectrum of 4-amino-5-fluoropyrin-3-ol (9b).

  Figure S14. {¹⁹F NMR} spectrum of 4-amino-5-fluoropyrin-3-ol (9b).

  Figure S15. Permeability rate of 3F4AP and controls.

  Figure S16. HPLC calibration curves of 3F4AP, 5OH3F4AP and 3F4AP N-oxide for logD and PAMPA assay.

  Figure S17. Spectrometry absorbance calibration curves of 5OH3F4AP and 3F4AP N-oxide for PAMPA assay.