Data Supplement

• 1401_supp_fig_1.pdf -

  Supplemental Figure 1. Scheme for generating JMS-053 resistant cells.
  

• 1401_supp_fig_2.pdf -

  Supplemental Figure 2. Representative cytotoxicity curves with A2780 WT (purple) and A2780 RES (blue) cells.
  

• 1401_supp_fig_3.pdf -

  Supplemental Figure 3. Representative cytotoxicity curves with OVCAR4 WT (purple) and OVCAR4 RES (blue) cells.
  

• 1401_supp_fig_4.pdf -

  Supplemental Figure 4. Quantification of Western blots of total SHP-2 (Panel A), STAT5 (Panel B), and Y694 pSTAT5 (Panel C) in OVCAR4 cells 7 min after exposure to JMS-053.
  

• 1401_supp_fig_5.pdf -

  Supplemental Figure 5. Full Western blots used to compose Figure 3C.
  

• 1401_supp_fig_6.pdf -

  Supplemental Figure 6. Full Western blots used to compose p-STAT3 Y705 (Panels A and B) and GAPDH (Panels C and D) in Figure 5A.
  

• 1401_supp_table_1.pdf -

  Supplemental Table 1. List of the suppliers, catalog number and lot number of reagents used in the study.