Data Supplement

• Supplemental Data -

  Supplemental Figure 1. PCR images showing the homozygosity of mouse genotypes for use in the current study.
  

  Supplemental Figure 2. Daily tolerance to the antinociceptive (A-D) and hypothermic (E-F) effects of once-daily
  administration of 30 mg/kg Δ9-THC (left panels) or 0.6 mg/kg CP55,940 (right panels) by sex.
  

  Supplemental Figure 3. Tolerance development to the antinociceptive [hot-plate (A-B) and tail-flick (C-D)] and
  hypothermic (E-F) effects of Δ9-THC (left panels) or 0.6 mg/kg CP55,940 (right panels) by sex via shifts in dose-response curves.
  

  Supplementary Table 1. THC Daily Tolerance
  

  Supplementary Table 2. CP55,940 Daily Tolerance
  

  Supplementary Table 3. THC Dose Response
  

  Supplementary Table 4. CP55,940 Dose Response