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OtherDrug Discovery and Translational Medicine

The Novel, Clinical Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease

Glenn A. Reinhart, Paul C. Harrison, Kathleen Lincoln, Hongxing Chen, Peng Sun, Jon Hill, Hu Sheng Qian, Mark McHugh, Holly Clifford, Khing Jow Ng, Hong Wang, Danielle Fowler, Kristina K. Gueneva-Boucheva, Todd Bosanac, Diane Wong, Ryan M. Fryer, Chris Sarko, Carine M Boustany-Kari and Steven S. Pullen
Journal of Pharmacology and Experimental Therapeutics December 6, 2022, JPET-AR-2022-001423; DOI: https://doi.org/10.1124/jpet.122.001423
Glenn A. Reinhart
1Boehringer Ingelheim Pharmaceuticals, United States
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Paul C. Harrison
2Cardiometabolic Diseases Research, Boehringer-Ingelheim Pharmaceuticals, United States
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Kathleen Lincoln
2Cardiometabolic Diseases Research, Boehringer-Ingelheim Pharmaceuticals, United States
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Hongxing Chen
3Boehringer Ingelheim Pharmaceuticals, Inc., United States
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Peng Sun
4Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc., United States
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Jon Hill
2Cardiometabolic Diseases Research, Boehringer-Ingelheim Pharmaceuticals, United States
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Hu Sheng Qian
3Boehringer Ingelheim Pharmaceuticals, Inc., United States
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Mark McHugh
3Boehringer Ingelheim Pharmaceuticals, Inc., United States
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Holly Clifford
3Boehringer Ingelheim Pharmaceuticals, Inc., United States
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Khing Jow Ng
2Cardiometabolic Diseases Research, Boehringer-Ingelheim Pharmaceuticals, United States
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Hong Wang
2Cardiometabolic Diseases Research, Boehringer-Ingelheim Pharmaceuticals, United States
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Danielle Fowler
2Cardiometabolic Diseases Research, Boehringer-Ingelheim Pharmaceuticals, United States
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Kristina K. Gueneva-Boucheva
5DDS, Boehringer-Ingelheim, United States
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Todd Bosanac
6Small Molecule Discovery Researcy, Boehringer-Ingelheim Pharmaceuticals, United States
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Diane Wong
2Cardiometabolic Diseases Research, Boehringer-Ingelheim Pharmaceuticals, United States
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Ryan M. Fryer
7Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc, United States
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Chris Sarko
6Small Molecule Discovery Researcy, Boehringer-Ingelheim Pharmaceuticals, United States
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Carine M Boustany-Kari
3Boehringer Ingelheim Pharmaceuticals, Inc., United States
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Steven S. Pullen
2Cardiometabolic Diseases Research, Boehringer-Ingelheim Pharmaceuticals, United States
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  • For correspondence: steven.pullen@boehringer-ingelheim.com
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Article Information

JPET-AR-2022-001423
DOI 
https://doi.org/10.1124/jpet.122.001423
PubMed 
36507845

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Published online December 6, 2022.

Article Versions

  • You are currently viewing an Earlier version of this article (December 6, 2022 - 09:04).
  • earlier version (February 21, 2023 - 05:25).
  • View the most recent version of this article
Copyright & Usage 
Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Glenn A. Reinhart1,
  2. Paul C. Harrison2,
  3. Kathleen Lincoln2,
  4. Hongxing Chen3,
  5. Peng Sun4,
  6. Jon Hill2,
  7. Hu Sheng Qian3,
  8. Mark McHugh3,
  9. Holly Clifford3,
  10. Khing Jow Ng2,
  11. Hong Wang2,
  12. Danielle Fowler2,
  13. Kristina K. Gueneva-Boucheva5,
  14. Todd Bosanac6,
  15. Diane Wong2,
  16. Ryan M. Fryer7,
  17. Chris Sarko6,
  18. Carine M Boustany-Kari3, and
  19. Steven S. Pullen2,*
  1. 1Boehringer Ingelheim Pharmaceuticals, United States
  2. 2Cardiometabolic Diseases Research, Boehringer-Ingelheim Pharmaceuticals, United States
  3. 3Boehringer Ingelheim Pharmaceuticals, Inc., United States
  4. 4Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc., United States
  5. 5DDS, Boehringer-Ingelheim, United States
  6. 6Small Molecule Discovery Researcy, Boehringer-Ingelheim Pharmaceuticals, United States
  7. 7Cardiometabolic Diseases Research, Boehringer Ingelheim Pharmaceuticals, Inc, United States
  1. ↵* Corresponding Author:
    Steven S. Pullen, Cardiometabolic Diseases Research, Boehringer-Ingelheim Pharmaceuticals, 900 Ridgebury Road, PO Box 368, Ridgebury, Connecticut, 06877-0368, United States. E-mail: steven.pullen{at}boehringer-ingelheim.com

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Article usage: December 2022 to March 2023

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Jan 20233030126
Feb 202387417201
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Journal of Pharmacology and Experimental Therapeutics: 385 (1)
Journal of Pharmacology and Experimental Therapeutics
Vol. 385, Issue 1
1 Apr 2023
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OtherDrug Discovery and Translational Medicine

Kidney protective effects of BI 685509

Glenn A. Reinhart, Paul C. Harrison, Kathleen Lincoln, Hongxing Chen, Peng Sun, Jon Hill, Hu Sheng Qian, Mark McHugh, Holly Clifford, Khing Jow Ng, Hong Wang, Danielle Fowler, Kristina K. Gueneva-Boucheva, Todd Bosanac, Diane Wong, Ryan M. Fryer, Chris Sarko, Carine M Boustany-Kari and Steven S. Pullen
Journal of Pharmacology and Experimental Therapeutics December 6, 2022, JPET-AR-2022-001423; DOI: https://doi.org/10.1124/jpet.122.001423

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OtherDrug Discovery and Translational Medicine

Kidney protective effects of BI 685509

Glenn A. Reinhart, Paul C. Harrison, Kathleen Lincoln, Hongxing Chen, Peng Sun, Jon Hill, Hu Sheng Qian, Mark McHugh, Holly Clifford, Khing Jow Ng, Hong Wang, Danielle Fowler, Kristina K. Gueneva-Boucheva, Todd Bosanac, Diane Wong, Ryan M. Fryer, Chris Sarko, Carine M Boustany-Kari and Steven S. Pullen
Journal of Pharmacology and Experimental Therapeutics December 6, 2022, JPET-AR-2022-001423; DOI: https://doi.org/10.1124/jpet.122.001423
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