Data Supplement

• Supplemental Data -

  Supplementary Table S1. Statistics for baseline measures of body weight, food consumption, body temperature, and observable signs in rats treated twice daily with vehicle, CBD, diazepam, or morphine.

  Supplementary Table S2. Statistics from the analysis of change scores in rats following discontinuation of twice daily treatment with vehicle, CBD, diazepam, or morphine (Figures 4 and 5).

  Supplemental Figure 1. Plasma levels of CBD and two metabolites, 7-COOH-CBD and 7-OH-CBD, in four rhesus monkeys following i.v. administration of 0.32, 1.0, or 3.2 mg/kg CBD.

  Supplemental Figure 2. Plasma levels of CBD and three metabolites, 7-COOH-CBD 7-OH-CBD, and 6-OH-CBD, in male Sprague-Dawley rats following i.v. administration of 0.081, 0.808 and 2.67 mg/kg CBD.

  Supplemental Figure 3. Plasma levels of CBD and three metabolites, 7-COOH-CBD, 7-OH-CBD, and 6-OH-CBD, in female Lister Hooded rats following p.o. administration of 20, 75, or 150 mg/kg CBD.