Intravenous and Intramuscular Allopregnanolone for Early Treatment of Status Epilepticus: Pharmacokinetics, Pharmacodynamics, and Safety in Dogs

Irene Vuu; Edward E Patterson; Chun-Yi Wu; Dorota Zolkowska; Ilo E Leppik; Michael A. Rogawski; Gregory A Worrell; Vaclav Kremen; James C Cloyd; Lisa D Coles

doi:10.1124/jpet.121.000736

OtherNeuropharmacology

Intravenous and Intramuscular Allopregnanolone for Early Treatment of Status Epilepticus: Pharmacokinetics, Pharmacodynamics, and Safety in Dogs

Irene Vuu, Edward E Patterson, Chun-Yi Wu, Dorota Zolkowska, Ilo E Leppik, Michael A. Rogawski, Gregory A Worrell, Vaclav Kremen, James C Cloyd and Lisa D Coles

Journal of Pharmacology and Experimental Therapeutics December 3, 2021, JPET-AR-2021-000736; DOI: https://doi.org/10.1124/jpet.121.000736

Irene Vuu

1Clinical Pharmacology Modeling and Simulation, Amgen Inc, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Irene Vuu

Edward E Patterson

2Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Chun-Yi Wu

3Department of Neurology, University of California, Davis School of Medicine, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Dorota Zolkowska

3Department of Neurology, University of California, Davis School of Medicine, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ilo E Leppik

4Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Michael A. Rogawski

5Department of Neurology, University of California, Davis, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gregory A Worrell

6Department of Neurology, Mayo Clinic, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Vaclav Kremen

6Department of Neurology, Mayo Clinic, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

James C Cloyd

7Experimental and Clinical Pharmacology, University of Minnesota, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lisa D Coles

4Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: durh0016@umn.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF + SI
PDF

Article Figures & Data

Additional Files

Data Supplement

Supplemental Figure 1
Supplemental Figure 2
Supplemental Figure 3
Supplemental Table 1
Supplemental Table 2
Supplemental Table 3

In this issue

Journal of Pharmacology and Experimental Therapeutics

Vol. 381, Issue 2

1 May 2022

Table of Contents
Table of Contents (PDF)
About the Cover
Index by author
Editorial Board (PDF)
Front Matter (PDF)

Download PDF

Article Alerts

User Name *

Password *

Email *

Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Intravenous and Intramuscular Allopregnanolone for Early Treatment of Status Epilepticus: Pharmacokinetics, Pharmacodynamics, and Safety in Dogs

Message Subject (Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics

Message Body (Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Citation Tools

OtherNeuropharmacology

Allopregnanolone PK-PD for Treatment of Status Epilepticus

Irene Vuu, Edward E Patterson, Chun-Yi Wu, Dorota Zolkowska, Ilo E Leppik, Michael A. Rogawski, Gregory A Worrell, Vaclav Kremen, James C Cloyd and Lisa D Coles

Journal of Pharmacology and Experimental Therapeutics December 3, 2021, JPET-AR-2021-000736; DOI: https://doi.org/10.1124/jpet.121.000736

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

OtherNeuropharmacology

Allopregnanolone PK-PD for Treatment of Status Epilepticus

Irene Vuu, Edward E Patterson, Chun-Yi Wu, Dorota Zolkowska, Ilo E Leppik, Michael A. Rogawski, Gregory A Worrell, Vaclav Kremen, James C Cloyd and Lisa D Coles

Journal of Pharmacology and Experimental Therapeutics December 3, 2021, JPET-AR-2021-000736; DOI: https://doi.org/10.1124/jpet.121.000736

Share This Article: