Intravenous and Intramuscular Allopregnanolone for Early Treatment of Status Epilepticus: Pharmacokinetics, Pharmacodynamics, and Safety in Dogs

Irene Vuu; Edward E Patterson; Chun-Yi Wu; Dorota Zolkowska; Ilo E Leppik; Michael A. Rogawski; Gregory A Worrell; Vaclav Kremen; James C Cloyd; Lisa D Coles

doi:10.1124/jpet.121.000736

OtherNeuropharmacology

Intravenous and Intramuscular Allopregnanolone for Early Treatment of Status Epilepticus: Pharmacokinetics, Pharmacodynamics, and Safety in Dogs

Irene Vuu, Edward E Patterson, Chun-Yi Wu, Dorota Zolkowska, Ilo E Leppik, Michael A. Rogawski, Gregory A Worrell, Vaclav Kremen, James C Cloyd and Lisa D Coles

Journal of Pharmacology and Experimental Therapeutics December 3, 2021, JPET-AR-2021-000736; DOI: https://doi.org/10.1124/jpet.121.000736

Irene Vuu

1Clinical Pharmacology Modeling and Simulation, Amgen Inc, United States

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ORCID record for Irene Vuu

Edward E Patterson

2Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, United States

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Chun-Yi Wu

3Department of Neurology, University of California, Davis School of Medicine, United States

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Dorota Zolkowska

3Department of Neurology, University of California, Davis School of Medicine, United States

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Ilo E Leppik

4Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, United States

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Michael A. Rogawski

5Department of Neurology, University of California, Davis, United States

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Gregory A Worrell

6Department of Neurology, Mayo Clinic, United States

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Vaclav Kremen

6Department of Neurology, Mayo Clinic, United States

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James C Cloyd

7Experimental and Clinical Pharmacology, University of Minnesota, United States

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Lisa D Coles

4Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, United States

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For correspondence: durh0016@umn.edu

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Journal of Pharmacology and Experimental Therapeutics

Vol. 381, Issue 2

1 May 2022

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OtherNeuropharmacology

Allopregnanolone PK-PD for Treatment of Status Epilepticus

Irene Vuu, Edward E Patterson, Chun-Yi Wu, Dorota Zolkowska, Ilo E Leppik, Michael A. Rogawski, Gregory A Worrell, Vaclav Kremen, James C Cloyd and Lisa D Coles

Journal of Pharmacology and Experimental Therapeutics December 3, 2021, JPET-AR-2021-000736; DOI: https://doi.org/10.1124/jpet.121.000736

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OtherNeuropharmacology

Allopregnanolone PK-PD for Treatment of Status Epilepticus

Irene Vuu, Edward E Patterson, Chun-Yi Wu, Dorota Zolkowska, Ilo E Leppik, Michael A. Rogawski, Gregory A Worrell, Vaclav Kremen, James C Cloyd and Lisa D Coles

Journal of Pharmacology and Experimental Therapeutics December 3, 2021, JPET-AR-2021-000736; DOI: https://doi.org/10.1124/jpet.121.000736

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