Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplemental Fig. 1: SAR439883 effect on Aβ42 oligomer (AO)-induced neurotoxicity in vitro.
Supplemental Fig. 2: Pharmacokinetic profile of SAR439883 in plasma and brain of WT mouse.
Supplemental Fig. 3: Effect of SAR439883 on peIF2alpha levels in hippocampus of C57Bl6 mouse...
Supplemental Fig. 4: Effect of SAR439883 on memory impairment in AβO i.c.v. mouse (MWM).
Supplemental Fig. 5: Effect of SAR439883 18-day diet treatment on peIF2alpha levels in AβO i.c.v. injection model.
Supplemental Table 1: SAR439883 selectivity profile using KiNativ™ technology...
Supplemental Table 2: Kinetics and associated pharmacodynamic response to SAR439883 treatment in diet in WT mice.
Supplemental Table 3: SAR439883 effect on Aβ42 oligomers (AO)-induced neurotoxicity in vitro: Effect on peIF2alpha levels.
Supplemental methods: Synthesis of SAR439883 compound.
- Supplemental Data -