OtherDrug Discovery and Translational Medicine
The small molecule BC-2059 inhibits Wnt-dependent gene transcription in cancer through disruption of the Transducin Beta-Like 1 (TBL1)-β-catenin protein complex
Raffaella Soldi, Tithi Ghosh Halder, Samuel Sampson, Hariprasad Vankayalapati, Alexis Weston, Trason Thode, Kapil Bhalla MD, Serina Ng, Ryan Rodriguez del Villar, Kevin Drenner, Mohan R Kaadige, Stephen K Horrigan, Surinder Batra, Ravi Salgia and Sunil Sharma
Journal of Pharmacology and Experimental Therapeutics May 18, 2021, JPET-AR-2021-000634; DOI: https://doi.org/10.1124/jpet.121.000634
Raffaella Soldi
1Applied Cancer Research and Drug Discovery, Translational Genomics Research Institute (TGen), United States
Tithi Ghosh Halder
2Translational Genomics Research Institute (TGen), United States
Samuel Sampson
2Translational Genomics Research Institute (TGen), United States
Hariprasad Vankayalapati
3Huntsman Cancer Institute, United States
Alexis Weston
2Translational Genomics Research Institute (TGen), United States
Trason Thode
2Translational Genomics Research Institute (TGen), United States
Kapil Bhalla MD
4MD Anderson Cancer Center, United States
Serina Ng
2Translational Genomics Research Institute (TGen), United States
Ryan Rodriguez del Villar
2Translational Genomics Research Institute (TGen), United States
Kevin Drenner
2Translational Genomics Research Institute (TGen), United States
Mohan R Kaadige
2Translational Genomics Research Institute (TGen), United States
Stephen K Horrigan
5Iterion Therapeutics, United States
Surinder Batra
6Biochemistry, UNMC, United States
Ravi Salgia
7City of Hope, United States
Sunil Sharma
2Translational Genomics Research Institute (TGen), United States
Article Figures & Data
Additional Files
Data Supplement
- Supplemental Table 1 -
List of primers used in ChIP Assay
- Supplemental Table 2 -
List of primers used in qPCR
- Supplemental Figure 1 -
Cytotoxicity of BC-2059 in TBL1 siRNA transfected HCT 15.
- Supplemental Figure 2 -
Co-IP β-catenin.
- Supplemental Table 1 -
In this issue
OtherDrug Discovery and Translational Medicine
Mechanism of Wnt pathway inhibition by BC-2059 in cancer
Raffaella Soldi, Tithi Ghosh Halder, Samuel Sampson, Hariprasad Vankayalapati, Alexis Weston, Trason Thode, Kapil Bhalla MD, Serina Ng, Ryan Rodriguez del Villar, Kevin Drenner, Mohan R Kaadige, Stephen K Horrigan, Surinder Batra, Ravi Salgia and Sunil Sharma
Journal of Pharmacology and Experimental Therapeutics May 18, 2021, JPET-AR-2021-000634; DOI: https://doi.org/10.1124/jpet.121.000634
OtherDrug Discovery and Translational Medicine
Mechanism of Wnt pathway inhibition by BC-2059 in cancer
Raffaella Soldi, Tithi Ghosh Halder, Samuel Sampson, Hariprasad Vankayalapati, Alexis Weston, Trason Thode, Kapil Bhalla MD, Serina Ng, Ryan Rodriguez del Villar, Kevin Drenner, Mohan R Kaadige, Stephen K Horrigan, Surinder Batra, Ravi Salgia and Sunil Sharma
Journal of Pharmacology and Experimental Therapeutics May 18, 2021, JPET-AR-2021-000634; DOI: https://doi.org/10.1124/jpet.121.000634
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