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Development of CVN424: a selective and novel GPR6 inverse agonist effective in models of Parkinson's Disease

Nicola L Brice, Hans H Schiffer, Holger Monenschein, Victoria J Mulligan, Keith Page, Justin Powell, Xiao Xu, Toni Cheung, J Russell Burley, Huikai Sun, Louise Dickson, Sean T Murphy, Nidhi Kaushal, Steven Sheardown, Jason Lawrence, Yun Chen, Darian Bartkowski, Anne Kanta, Joseph Russo, Natalie Hosea, Lee A Dawson, Stephen H Hitchcock and Mark B Carlton
Journal of Pharmacology and Experimental Therapeutics April 1, 2021, JPET-AR-2020-000438; DOI: https://doi.org/10.1124/jpet.120.000438

Article Information

JPET-AR-2020-000438
DOI 
https://doi.org/10.1124/jpet.120.000438
PubMed 
33795395
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Published online April 1, 2021.
Copyright & Usage 
Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Nicola L Brice1,*,
  2. Hans H Schiffer2,
  3. Holger Monenschein2,
  4. Victoria J Mulligan3,
  5. Keith Page3,
  6. Justin Powell3,
  7. Xiao Xu3,
  8. Toni Cheung4,
  9. J Russell Burley3,
  10. Huikai Sun2,
  11. Louise Dickson4,
  12. Sean T Murphy2,
  13. Nidhi Kaushal2,
  14. Steven Sheardown4,
  15. Jason Lawrence4,
  16. Yun Chen2,
  17. Darian Bartkowski2,
  18. Anne Kanta2,
  19. Joseph Russo2,
  20. Natalie Hosea5,
  21. Lee A Dawson3,
  22. Stephen H Hitchcock2, and
  23. Mark B Carlton3
  1. 1Cerevance, United Kingdom
  2. 2Takeda California, United States of America
  3. 3Cerevance Ltd, United Kingdom
  4. 4Cerevance Ltd., United Kingdom
  5. 5Drug Metabolism and Pharmacokinetics, United States of America
  1. ↵* Corresponding Author:
    Nicola L Brice, Cerevance, 418 Cambridge Science Park, Cambridge, N/A, United Kingdom. E-mail: nicola.brice{at}cerevance.com

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OtherNeuropharmacology

CVN424, a novel GPR6 inverse agonist for Parkinson's disease

Nicola L Brice, Hans H Schiffer, Holger Monenschein, Victoria J Mulligan, Keith Page, Justin Powell, Xiao Xu, Toni Cheung, J Russell Burley, Huikai Sun, Louise Dickson, Sean T Murphy, Nidhi Kaushal, Steven Sheardown, Jason Lawrence, Yun Chen, Darian Bartkowski, Anne Kanta, Joseph Russo, Natalie Hosea, Lee A Dawson, Stephen H Hitchcock and Mark B Carlton
Journal of Pharmacology and Experimental Therapeutics April 1, 2021, JPET-AR-2020-000438; DOI: https://doi.org/10.1124/jpet.120.000438
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