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OtherCellular and Molecular

Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish

Leilei Zhang, Seok-Hyung Kim, Ki-Hoon Park, Zhi-wei Ye, Jie Zhang, Danyelle Townsend and Kenneth D. Tew
Journal of Pharmacology and Experimental Therapeutics February 18, 2021, JPET-AR-2020-000417; DOI: https://doi.org/10.1124/jpet.120.000417
Leilei Zhang
1MUSC, United States
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Seok-Hyung Kim
2MUSC, United States of America
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Ki-Hoon Park
2MUSC, United States of America
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Zhi-wei Ye
3Departments of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, United States of America
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Jie Zhang
2MUSC, United States of America
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Danyelle Townsend
4Department of Experimental Therapeutics, Medical University of South Carolina, United States
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Kenneth D. Tew
5Department of Pharmacology, MUSC, United States
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  • For correspondence: tewk@musc.edu
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    • Supplemental Data -

      Figure S1. Protein homology comparison of human GSTP1 and zebrafish Gstp1.

      Figure S2. Gstp1 KO zebrafish embryos and larvae appeared healthy, with no obvious defects during development compare with wild type.

      Figure S3. ER stress/UPR protein expression.

      Table S1. Primer sequences used for qPCRs.


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Journal of Pharmacology and Experimental Therapeutics: 376 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 376, Issue 3
1 Mar 2021
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OtherCellular and Molecular

Zebrafish Gstp1 drug response

Leilei Zhang, Seok-Hyung Kim, Ki-Hoon Park, Zhi-wei Ye, Jie Zhang, Danyelle Townsend and Kenneth D. Tew
Journal of Pharmacology and Experimental Therapeutics February 18, 2021, JPET-AR-2020-000417; DOI: https://doi.org/10.1124/jpet.120.000417

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OtherCellular and Molecular

Zebrafish Gstp1 drug response

Leilei Zhang, Seok-Hyung Kim, Ki-Hoon Park, Zhi-wei Ye, Jie Zhang, Danyelle Townsend and Kenneth D. Tew
Journal of Pharmacology and Experimental Therapeutics February 18, 2021, JPET-AR-2020-000417; DOI: https://doi.org/10.1124/jpet.120.000417
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