Data Supplement

• Supplemental Data -

  Supplemental Methods

  Figure S1. Evaluation of positive inotropic effect of SAR296968 on isolated canine ventricular cardiomyocytes under HF conditions.

  Table S1. Echocardiographic parameters.

  Table S2. Effects of SAR296968 (1 and 3 μM) on contractility parameters...

  Table S3a. Effect of SAR296968 on the left ventricular repolarization and the QRS interval...
  

  Table S3b. Effect of SAR296968 on left and right atria refractory periods in anesthetized pigs...

  Table S4. Effect of SAR296968 on contraction and relaxation of failing cardiomyocytes...

  Table S5. Effect of SAR296968 on contraction and relaxation of Normal cardiomyocytes from Beagles.

  Table S6. CEREP selectivity profile (78 targets).