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OtherDrug Discovery and Translational Medicine

SAR340835, a novel selective NCX inhibitor, improves cardiac function and restores sympathovagal balance in Heart Failure.

Michel Pelat, Fabrice Barbe, Cyril Daveu, Laetitia Ly-Nguyen, Thomas Lartigue, Suzanne Marque, Georges Tavares, Veronique Ballet, Jean-Michel Guillon, Klaus Steinmeyer, Klaus Wirth, Heinz Gögelein, Petra Arndt, Nils Rackelmann, John Weston, Patrice Bellevergue, Gary McCort, Marc Trellu, Laurence Lucats, Philippe Beauverger, Marie-Pierre Pruniaux-Harnist, Philip Janiak and Frédérique Chézalviel-Guilbert
Journal of Pharmacology and Experimental Therapeutics February 18, 2021, JPET-AR-2020-000238; DOI: https://doi.org/10.1124/jpet.120.000238
Michel Pelat
1Cardiovascular and Metabolism TSU, SANOFI R&D, France
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Fabrice Barbe
1Cardiovascular and Metabolism TSU, SANOFI R&D, France
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Cyril Daveu
1Cardiovascular and Metabolism TSU, SANOFI R&D, France
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Laetitia Ly-Nguyen
2Preclinical Safety, SANOFI R&D, France
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Thomas Lartigue
1Cardiovascular and Metabolism TSU, SANOFI R&D, France
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Suzanne Marque
1Cardiovascular and Metabolism TSU, SANOFI R&D, France
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Georges Tavares
31 avenue Pierre Brossolette, SANOFI R&D, France
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Veronique Ballet
2Preclinical Safety, SANOFI R&D, France
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Jean-Michel Guillon
2Preclinical Safety, SANOFI R&D, France
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Klaus Steinmeyer
4SANOFI R&D Industriepark Höchst, Germany
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Klaus Wirth
4SANOFI R&D Industriepark Höchst, Germany
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Heinz Gögelein
5SANOFI R&D Industriepark Höchst, France
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Petra Arndt
4SANOFI R&D Industriepark Höchst, Germany
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Nils Rackelmann
4SANOFI R&D Industriepark Höchst, Germany
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John Weston
4SANOFI R&D Industriepark Höchst, Germany
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Patrice Bellevergue
6Integrated Drug Discovery, SANOFI R&D, France
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Gary McCort
6Integrated Drug Discovery, SANOFI R&D, France
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Marc Trellu
2Preclinical Safety, SANOFI R&D, France
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Laurence Lucats
1Cardiovascular and Metabolism TSU, SANOFI R&D, France
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Philippe Beauverger
1Cardiovascular and Metabolism TSU, SANOFI R&D, France
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Marie-Pierre Pruniaux-Harnist
1Cardiovascular and Metabolism TSU, SANOFI R&D, France
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Philip Janiak
7SANOFI R&D, France
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Frédérique Chézalviel-Guilbert
1Cardiovascular and Metabolism TSU, SANOFI R&D, France
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  • For correspondence: Frederique.Guilbert@sanofi.com
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Article Information

JPET-AR-2020-000238
DOI 
https://doi.org/10.1124/jpet.120.000238
PubMed 
33602875

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Published online February 18, 2021.

Copyright & Usage 
© 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited and is not used for commercial purposes.

Author Information

  1. Michel Pelat1,
  2. Fabrice Barbe1,
  3. Cyril Daveu1,
  4. Laetitia Ly-Nguyen2,
  5. Thomas Lartigue1,
  6. Suzanne Marque1,
  7. Georges Tavares3,
  8. Veronique Ballet2,
  9. Jean-Michel Guillon2,
  10. Klaus Steinmeyer4,
  11. Klaus Wirth4,
  12. Heinz Gögelein5,
  13. Petra Arndt4,
  14. Nils Rackelmann4,
  15. John Weston4,
  16. Patrice Bellevergue6,
  17. Gary McCort6,
  18. Marc Trellu2,
  19. Laurence Lucats1,
  20. Philippe Beauverger1,
  21. Marie-Pierre Pruniaux-Harnist1,
  22. Philip Janiak7, and
  23. Frédérique Chézalviel-Guilbert1,*
  1. 1Cardiovascular and Metabolism TSU, SANOFI R&D, France
  2. 2Preclinical Safety, SANOFI R&D, France
  3. 31 avenue Pierre Brossolette, SANOFI R&D, France
  4. 4SANOFI R&D Industriepark Höchst, Germany
  5. 5SANOFI R&D Industriepark Höchst, France
  6. 6Integrated Drug Discovery, SANOFI R&D, France
  7. 7SANOFI R&D, France
  1. ↵* Corresponding Author:
    Frédérique Chézalviel-Guilbert, Cardiovascular and Metabolism TSU, SANOFI R&D, 1 avenue pierre Brossolette, Chilly Mazarin, N/A, 91385, France. E-mail: Frederique.Guilbert{at}sanofi.com

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Journal of Pharmacology and Experimental Therapeutics: 376 (3)
Journal of Pharmacology and Experimental Therapeutics
Vol. 376, Issue 3
1 Mar 2021
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OtherDrug Discovery and Translational Medicine

Pharmacology profile of NCX inhibitor in Heart Failure

Michel Pelat, Fabrice Barbe, Cyril Daveu, Laetitia Ly-Nguyen, Thomas Lartigue, Suzanne Marque, Georges Tavares, Veronique Ballet, Jean-Michel Guillon, Klaus Steinmeyer, Klaus Wirth, Heinz Gögelein, Petra Arndt, Nils Rackelmann, John Weston, Patrice Bellevergue, Gary McCort, Marc Trellu, Laurence Lucats, Philippe Beauverger, Marie-Pierre Pruniaux-Harnist, Philip Janiak and Frédérique Chézalviel-Guilbert
Journal of Pharmacology and Experimental Therapeutics February 18, 2021, JPET-AR-2020-000238; DOI: https://doi.org/10.1124/jpet.120.000238

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OtherDrug Discovery and Translational Medicine

Pharmacology profile of NCX inhibitor in Heart Failure

Michel Pelat, Fabrice Barbe, Cyril Daveu, Laetitia Ly-Nguyen, Thomas Lartigue, Suzanne Marque, Georges Tavares, Veronique Ballet, Jean-Michel Guillon, Klaus Steinmeyer, Klaus Wirth, Heinz Gögelein, Petra Arndt, Nils Rackelmann, John Weston, Patrice Bellevergue, Gary McCort, Marc Trellu, Laurence Lucats, Philippe Beauverger, Marie-Pierre Pruniaux-Harnist, Philip Janiak and Frédérique Chézalviel-Guilbert
Journal of Pharmacology and Experimental Therapeutics February 18, 2021, JPET-AR-2020-000238; DOI: https://doi.org/10.1124/jpet.120.000238
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