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Understanding exposure-receptor occupancy relationships for metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators across a range of pre-clinical and clinical studies

Kirstie A Bennett, Eugenia Sergeev, Cliona P MacSweeney, Geor Bakker and Anne E Cooper
Journal of Pharmacology and Experimental Therapeutics February 4, 2021, JPET-AR-2020-000371; DOI: https://doi.org/10.1124/jpet.120.000371
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OtherDrug Discovery and Translational Medicine

Exposure-receptor occupancy relationships for mGlu5 NAMs

Kirstie A Bennett, Eugenia Sergeev, Cliona P MacSweeney, Geor Bakker and Anne E Cooper
Journal of Pharmacology and Experimental Therapeutics February 4, 2021, JPET-AR-2020-000371; DOI: https://doi.org/10.1124/jpet.120.000371
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