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Understanding exposure-receptor occupancy relationships for metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators across a range of pre-clinical and clinical studies

Kirstie A Bennett, Eugenia Sergeev, Cliona P MacSweeney, Geor Bakker and Anne E Cooper
Journal of Pharmacology and Experimental Therapeutics February 4, 2021, JPET-AR-2020-000371; DOI: https://doi.org/10.1124/jpet.120.000371

Article Information

JPET-AR-2020-000371
DOI 
https://doi.org/10.1124/jpet.120.000371
PubMed 
33541889
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Published online February 4, 2021.

Article Versions

Copyright & Usage 
© 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited and is not used for commercial purposes.

Author Information

  1. Kirstie A Bennett1,
  2. Eugenia Sergeev2,*,
  3. Cliona P MacSweeney1,
  4. Geor Bakker1, and
  5. Anne E Cooper1
  1. 1Sosei Heptares, United Kingdom
  2. 2Molecular Pharmacology, Sosei Heptares, United Kingdom
  1. ↵* Corresponding Author:
    Eugenia Sergeev, Molecular Pharmacology, Sosei Heptares, Steinmetz Building, Granta Park, Cambridge, N/A, CB21 6DG, United Kingdom. E-mail: eugenia.sergeev{at}soseiheptares.com

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OtherDrug Discovery and Translational Medicine

Exposure-receptor occupancy relationships for mGlu5 NAMs

Kirstie A Bennett, Eugenia Sergeev, Cliona P MacSweeney, Geor Bakker and Anne E Cooper
Journal of Pharmacology and Experimental Therapeutics February 4, 2021, JPET-AR-2020-000371; DOI: https://doi.org/10.1124/jpet.120.000371
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