A novel mitochondrial complex of P450c11AS, StAR and Tom22 synthesizes aldosterone in the rat heart

Himangshu S. Bose; Randy M Whittal; Brendan Marshall; Maheshinie S Rajapaksha; Ning Ping Wang; Madhuchanda Bose; Elizabeth W Perry; Zhi-Qing Zhao; Walter L Miller

doi:10.1124/jpet.120.000365

OtherCellular and Molecular

A novel mitochondrial complex of P450c11AS, StAR and Tom22 synthesizes aldosterone in the rat heart

Himangshu S. Bose, Randy M Whittal, Brendan Marshall, Maheshinie S Rajapaksha, Ning Ping Wang, Madhuchanda Bose, Elizabeth W Perry, Zhi-Qing Zhao and Walter L Miller

Journal of Pharmacology and Experimental Therapeutics February 1, 2021, JPET-AR-2020-000365; DOI: https://doi.org/10.1124/jpet.120.000365

Himangshu S. Bose

1Biomedical Sciences, Mercer U School of Medicine, United States of America

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For correspondence: bosehs@gmail.com

Randy M Whittal

2Chemistry, University of Alberta, Canada

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Brendan Marshall

3Medical College of Georgia, United States of America

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Maheshinie S Rajapaksha

4Biomedical Sciences, Mercer University, United States of America

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Ning Ping Wang

4Biomedical Sciences, Mercer University, United States of America

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Madhuchanda Bose

5Innovation Center, University of Florida, United States of America

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Elizabeth W Perry

6Anatomy and Cell Biology, Medical College of Georgia, United States of America

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Zhi-Qing Zhao

7Basic Biomedical Sciences, Mercer University, United States of America

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Walter L Miller

8Pediatrics, UCSF, United States of America

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Fig. S1: Identification of Tom22 interaction with StAR and P450c11AS by chemical crosslinking following AngII stimulation of H9c2 cells without and with StAR knockdown.

Fig. S2: Identification of StAR interaction with P450c11AS and Tom22 by chemical crosslinking following AngII stimulation in presence and absence of siRNA against StAR.

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Journal of Pharmacology and Experimental Therapeutics

Vol. 378, Issue 1

1 Jul 2021

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OtherCellular and Molecular

Aldosterone synthesis in the heart

Himangshu S. Bose, Randy M Whittal, Brendan Marshall, Maheshinie S Rajapaksha, Ning Ping Wang, Madhuchanda Bose, Elizabeth W Perry, Zhi-Qing Zhao and Walter L Miller

Journal of Pharmacology and Experimental Therapeutics February 1, 2021, JPET-AR-2020-000365; DOI: https://doi.org/10.1124/jpet.120.000365

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OtherCellular and Molecular

Aldosterone synthesis in the heart

Himangshu S. Bose, Randy M Whittal, Brendan Marshall, Maheshinie S Rajapaksha, Ning Ping Wang, Madhuchanda Bose, Elizabeth W Perry, Zhi-Qing Zhao and Walter L Miller

Journal of Pharmacology and Experimental Therapeutics February 1, 2021, JPET-AR-2020-000365; DOI: https://doi.org/10.1124/jpet.120.000365

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