Article Figures & Data
Additional Files
Data Supplement
- Supplemental Figures -
Figure S1. Effects of the s.c. administration of TRAM-34 (10 mg/kg, s.c.) on the clinical assessment (diarrhea and bloody feces) and colonic inflammation in IBD model mice.
Figure S2. Expression levels of pro-inflammatory cytokines (IFN-γ and IL-17F) in mLN CD4+CD25- T cells in the induction and recovery phases in IBD model mice.
Figure S3. Increased IL-10, CD25, and Foxp3 expression in mLN tissues in the recovery phase in IBD model mice, but not in the induction phase.
Figure S4. Effects of TRAM-34 (1 mg/kg, s.c.) administration on the population of the CD4+CD25+ Treg cell subset and the expression level of CD25 in CD4+CD25+ Treg cells.
Figure S5. No changes in transcriptional expression levels of KCa3.1, HDAC2, HDAC3, and KCa3.1 modulatory Beta subunits...
Figure S6. Expression levels of transcriptional regulators for IL-10 by the administration of TRAM-34 in mLN CD4+CD25+ Treg cells in the recovery phase in IBD model mice.
Figure S7. Expression levels of transcriptional regulators for IL-17A in mLN CD4+CD25+ Treg cells in the recovery phase in IBD model mice...
Figure S8. Effects of signaling pathway inhibitors for ERK1/2, AKT, STAT3, CN, CaMKII, and TGF-β on IL-10 and IL-17A secretion...
Figure S9. Effects of a treatment with 10 μM TRAM-34 on the nuclear translocation of PSmad2 and P-Smad3 in Con-A-differentiated peripheral Treg cells.
- Supplemental Figures -