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Journal of Pharmacology and Experimental Therapeutics

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OtherCardiovascular

Acetate, a Short-Chain Fatty Acid, Acutely Lowers Heart Rate and Cardiac Contractility along with Blood Pressure

Brian G Poll, Jiaojiao Xu, Seungho Jun, Jason Sanchez, Nathan Zaidman, Xiaojun He, Laeben Lester, Dan Berkowitz, Nazareno Paolocci, Wei Dong Gao and Jennifer Pluznick
Journal of Pharmacology and Experimental Therapeutics January 7, 2021, JPET-AR-2020-000187; DOI: https://doi.org/10.1124/jpet.120.000187
Brian G Poll
1Physiology, Johns Hopkins University School of Medicine, United States of America
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  • ORCID record for Brian G Poll
Jiaojiao Xu
1Physiology, Johns Hopkins University School of Medicine, United States of America
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Seungho Jun
2Traylor 911, Division of Cardiology, 720 Rutland Ave, Johns Hopkins University School of Medicine, United States of America
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Jason Sanchez
1Physiology, Johns Hopkins University School of Medicine, United States of America
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Nathan Zaidman
1Physiology, Johns Hopkins University School of Medicine, United States of America
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Xiaojun He
3Anesthesiology, Johns Hopkins University School of Medicine, United States of America
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Laeben Lester
4Johns Hopkins University School of Medicine, United States of America
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Dan Berkowitz
5University of Alabama at Birmingham School of Medicine, United States of America
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Nazareno Paolocci
6Medicine, Johns Hopkins Medical Institutions, United States of America
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Wei Dong Gao
7ACCM, Johns Hopkins University, United States of America
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Jennifer Pluznick
4Johns Hopkins University School of Medicine, United States of America
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  • For correspondence: jpluznick@jhmi.edu
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      Figure 1: Hemodynamic Parameters following SCFA intraperitoneal (IP) injection in radiotelemetry-implanted mice.

      Figure 2A: Hemodynamic Parameters following SCFA IP injection in radiotelemetry mice pre-treated with atenolol.

      Figure 2B: Hemodynamic Parameters following SCFA IP injection in radiotelemetry mice pre-treated with atropine.

      Figure 2C: Hemodynamic parameters following SCFA IP injection in radiotelemetry mice pre-treated with metoprolol.

      Figure 3: Hemodynamic parameters following SCFA IP injection in radiotelemetry mice pre-treated with Tyramine.

      Figure 4: Hemodynamic Parameters following IP injection of Propionate, Butyrate, and Lactate.

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Journal of Pharmacology and Experimental Therapeutics: 376 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 376, Issue 2
1 Feb 2021
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OtherCardiovascular

Effect of Acetate and on HR, BP, and Cardiac Contractility

Brian G Poll, Jiaojiao Xu, Seungho Jun, Jason Sanchez, Nathan Zaidman, Xiaojun He, Laeben Lester, Dan Berkowitz, Nazareno Paolocci, Wei Dong Gao and Jennifer Pluznick
Journal of Pharmacology and Experimental Therapeutics January 7, 2021, JPET-AR-2020-000187; DOI: https://doi.org/10.1124/jpet.120.000187

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OtherCardiovascular

Effect of Acetate and on HR, BP, and Cardiac Contractility

Brian G Poll, Jiaojiao Xu, Seungho Jun, Jason Sanchez, Nathan Zaidman, Xiaojun He, Laeben Lester, Dan Berkowitz, Nazareno Paolocci, Wei Dong Gao and Jennifer Pluznick
Journal of Pharmacology and Experimental Therapeutics January 7, 2021, JPET-AR-2020-000187; DOI: https://doi.org/10.1124/jpet.120.000187
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