Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplemental Methods: In Vitro [35S]GTPyS Functional Assay at opioid receptor subtypes.
Supplemental Table 1: Summary of the methods used to determine functional effects of mitragynine at the delta-, kappa-, and muopioid receptors from Eurofins Cerep.
Supplemental Table 2: Statistical analyses of sex differences in dose-effect functions for the discriminative-stimulus...
Supplemental Table 3: ED50 values (95% CIs) for the discriminative-stimulus, rate-decreasing, and antinociceptive effects...
Supplemental Table 4: Comparison of potency ratios of various compounds tested to produce the discriminative stimulus, rate-decreasing, and antinociceptive effects...
Supplemental Figure 1. Concentration-effect curves of mitragynine in stimulating [35S]GTPγS binding in CHO cell lines...
Supplemental Figure 2. Antagonism of DPDPE agonist effects (unspecified from Eurofins Cerep) by mitragynine...
Supplemental Figure 3. Antagonism of U69,593 agonist effects (unspecified from Eurofins Cerep) by mitragynine...
Supplemental Figure 4. Antagonism of DAMGO agonist effects (unspecified from Eurofins Cerep) by mitragynine...
Supplemental Figure 5. Discriminative-stimulus effects in separate groups of rats discriminating either morphine or mitragynine, divided by sex.
Supplemental Figure 6. Antinociceptive effects in separate groups of rats discriminating either morphine or mitragynine, divided by sex.
Supplemental Figure 7. Effects of sex on substitution of morphine or fentanyl for mitragynine. Abscissae: Vehicle and drug dose in mg/kg (i.p., log scale).
- Supplemental Data -