Data Supplement

• Supplemental Data -

  Supplemental Table 1. Optimization of epichlorohydrin crosslinked PAA-PDA copolymer hydrogel networks to identify SAR442357.

  Supplemental Figure S1. SAR442357: (A) Schematic representation of the synthesis of copolymer sequestrants by epichlorohydrin mediated crosslinking of PAA and PDA; and (B) 2-dimensional 13C-1H cross correlation NMR spectrum of SAR442357.

  Supplemental Figure S2. Gene expression Volcano plots.

  Supplemental Figure S3. Gene expression heatmap.

  Supplemental Figure S4. Serum liver safety parameters at study end after 3 months of treatment.

  Supplemental Figure S5. Serum and urine uric acid at study end after 3 months of treatment.

  Supplemental Figure S6. Kidney histology depicting tubule pathology in corticomedullary junction region.

  Supplemental Figure S7. The serum biomarkers of chronic tubular damage serum urea and serum creatinine at study end after 3 months of treatment.