Data Supplement

• Supplemental Data -

  Supplemental Table 1. Binding affinity values and cooperativity factors for melatonin, luzindole, and carbaryl at hMT1 and hMT2 melatonin receptors expressed in CHO cells.

  Supplemental Table 2. 2-[125I]-Iodomelatonin binding dissociation rates from hMT1 and hMT2 melatonin receptors ...

  Supplemental Table 3. Additional information regarding descriptive statistics and analyses for Fig. 7, Fig. 8, & Fig. 9.

  Supplemental Table 4. Additional information regarding descriptive statistics and analyses for Supplemental Fig. 5 quantitative receptor autoradiography results.
  

  Supplemental Table 5. Affinity constants of carbaryl for 2-[125I]-iodomelatonin binding to SCN, PVT, and PT in brain slices from C3H/HeN WT & MT2KO mice.

  Supplemental Figure 1. Molecular docking of carbaryl with human MT1 and MT2 melatonin receptor models derived from X-ray crystal structures.

  Supplemental Figure 2. Characterization of 2-[125I]-iodomelatonin binding mechanism for melatonin and luzindole.
  

  Supplemental Figure 3. Cluster 1-carbamate insecticides likely bind to melatonin receptor orthosteric sites.

  Supplemental Figure 4. Carbamate insecticides compete for 2-[125I]-iodomelatonin binding to hMT1 and hMT2 melatonin receptors...

  Supplemental Figure 5. Quantitative receptor autoradiography demonstrates bendiocarb and fenobucarb competes in-vitro for 2-[125I]-iodomelatonin binding...