Data Supplement

• Supplemental Data -

  Supplementary Figure 1. Calculation of cell volumes.

  Supplementary Figure 2. Calculation of lysosomal volume fractions.

  Supplementary Figure 3. Static PK Model Accounts for Variability Introduced by Modifying pH Parameters.

  Supplementary Figure 4. HCQ and Torin1 treatment causes an increase in lysosomes within the cell.

  Supplementary Figure 5. HCQ treatment causes lysosomal swelling.

  Table S1. Model Parameters.

  Table S2. Static Model Metrics (Performance Error).

  Table S3. Dynamic Model Metrics (Performance Error).

  Table S4. TFEB Dynamic Model Metrics (Performance Error).