Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplementary Figure 1 - Inhibitory effects of kratom extracts (coded K-50, K-51, and K-52) and mitragynine on
cytochrome P450 (CYP) 2C9 (diclofenac 4′-hydroxylation) (A), CYP2D6 (dextromethorphan Odemethylation) (B), and CYP3A (midazolam 1′-hydroxylation) (C) activities in HLMs and CYP3A (D) activity in HIMs. Extracts were tested at 2, 10, and 20 µg/mL; mitragynine was tested at 1, 10, and 100 µM. Positive control inhibitors included sulfaphenazole (1 µM), quinidine (2 µM), and ketoconazole (0.1 µM) for CYP2C9, CYP2D6, and CYP3A, respectively.Supplementary Figure 2 - Representative Lineweaver–Burk plot showing inhibition of CYP2D6-mediated
dextromethorphan O-demethylation by mitragynine (0.37-10 µM) in HLMs.
- Supplemental Data -