OtherNeuropharmacology
A Novel Potent and Selective Histamine H3 Receptor Antagonist Enerisant: In Vitro Profiles, In Vivo Receptor Occupancy, Wake-Promoting and Pro-cognitive Effects in Rodents
Noriko Hino, Toshiyuki Marumo, Makiko Kotani, Toshiharu Shimazaki, Ayaka Kaku-Fukumoto, Hirohiko Hikichi, Jun-ichi Karasawa, Yasumitsu Tomishima, Hiroko Komiyama, Emi Tatsuda, Dai Nozawa, Toshio Nakamura and Shigeyuki Chaki
Journal of Pharmacology and Experimental Therapeutics August 29, 2020, JPET-AR-2020-000185; DOI: https://doi.org/10.1124/jpet.120.000185
Noriko Hino
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan
Toshiyuki Marumo
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan
Makiko Kotani
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan
Toshiharu Shimazaki
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan
Ayaka Kaku-Fukumoto
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan
Hirohiko Hikichi
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan
Jun-ichi Karasawa
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan
Yasumitsu Tomishima
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan
Hiroko Komiyama
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan
Emi Tatsuda
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan
Dai Nozawa
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan
Toshio Nakamura
2Taisho Pharmaceutical Co., Ltd., Japan
Shigeyuki Chaki
1Research Headquarters, Taisho Pharmaceutical Co., Ltd., Japan

Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplementary Figure 1 - Profiles of TASP0410461.
Supplementary Table 1 - Electivity of enerisant over 70 receptors, ion channels, and transporters.
Supplementary Table 2 - Selectivity of enerisant over 45 enzymes.
- Supplemental Data -
In this issue
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Pharmacological profiles of enelisant
Noriko Hino, Toshiyuki Marumo, Makiko Kotani, Toshiharu Shimazaki, Ayaka Kaku-Fukumoto, Hirohiko Hikichi, Jun-ichi Karasawa, Yasumitsu Tomishima, Hiroko Komiyama, Emi Tatsuda, Dai Nozawa, Toshio Nakamura and Shigeyuki Chaki
Journal of Pharmacology and Experimental Therapeutics August 29, 2020, JPET-AR-2020-000185; DOI: https://doi.org/10.1124/jpet.120.000185
OtherNeuropharmacology
Pharmacological profiles of enelisant
Noriko Hino, Toshiyuki Marumo, Makiko Kotani, Toshiharu Shimazaki, Ayaka Kaku-Fukumoto, Hirohiko Hikichi, Jun-ichi Karasawa, Yasumitsu Tomishima, Hiroko Komiyama, Emi Tatsuda, Dai Nozawa, Toshio Nakamura and Shigeyuki Chaki
Journal of Pharmacology and Experimental Therapeutics August 29, 2020, JPET-AR-2020-000185; DOI: https://doi.org/10.1124/jpet.120.000185