Research ArticleDrug Discovery and Translational Medicine
Pharmacologic characterization of JNJ-42226314, [1-(4-fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a reversible, selective and potent monoacylglycerol lipase inhibitor
Ryan M Wyatt, Ian Fraser, Natalie Welty, Brian Lord, Michelle Wennerholm, Steven W Sutton, Michael K Ameriks, Christine Dugovic, Sujin Yun, Allison White, Leslie Nguyen, Tatiana Koudriakova, Gaochao Tian, Javier Suarez, Lawrence Szewczuk, William Bonnette, Kay Ahn, Brahma Ghosh, Christopher M Flores, Peter J Connolly, Bin Zhu, Mark J Macielag, Michael R Brandt, Kristen Chevalier, Sui-Po Zhang, Timothy W. Lovenberg and Pascal Bonaventure
Journal of Pharmacology and Experimental Therapeutics December 9, 2019, jpet.119.262139; DOI: https://doi.org/10.1124/jpet.119.262139
Ryan M Wyatt
Janssen Research and Development, LLC.
Ian Fraser
Janssen Research and Development, LLC.
Natalie Welty
Janssen Research and Development, LLC.
Brian Lord
Janssen Research and Development, LLC.
Michelle Wennerholm
Janssen Research and Development, LLC.
Steven W Sutton
Janssen Research and Development, LLC.
Michael K Ameriks
Janssen Research and Development, LLC.
Christine Dugovic
Janssen Research and Development, LLC.
Sujin Yun
Janssen Research and Development, LLC.
Allison White
Janssen Research and Development, LLC.
Leslie Nguyen
Janssen Research and Development, LLC.
Tatiana Koudriakova
Janssen Research and Development, LLC.
Gaochao Tian
Janssen Research and Development, LLC.
Javier Suarez
Janssen Research and Development, LLC.
Lawrence Szewczuk
Janssen Research and Development, LLC.
William Bonnette
Janssen Research and Development, LLC.
Kay Ahn
Janssen Research and Development, LLC.
Brahma Ghosh
Janssen Research and Development, LLC.
Christopher M Flores
Janssen Research and Development, LLC.
Peter J Connolly
Janssen Research and Development, LLC.
Bin Zhu
Janssen Research and Development, LLC.
Mark J Macielag
Janssen Research and Development, LLC.
Michael R Brandt
Janssen Research and Development, LLC.
Kristen Chevalier
Janssen Research and Development, LLC.
Sui-Po Zhang
Janssen Research and Development, LLC.
Timothy W. Lovenberg
Janssen Research and Development, LLC.
Pascal Bonaventure
Janssen Research and Development, LLC.
Article Figures & Data
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Data Supplement
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Supplemental methods, 3 figures.
- Supplemental Data -
In this issue
Research ArticleDrug Discovery and Translational Medicine
Pharmacologic characterization of JNJ-42226314, [1-(4-fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a reversible, selective and potent monoacylglycerol lipase inhibitor
Ryan M Wyatt, Ian Fraser, Natalie Welty, Brian Lord, Michelle Wennerholm, Steven W Sutton, Michael K Ameriks, Christine Dugovic, Sujin Yun, Allison White, Leslie Nguyen, Tatiana Koudriakova, Gaochao Tian, Javier Suarez, Lawrence Szewczuk, William Bonnette, Kay Ahn, Brahma Ghosh, Christopher M Flores, Peter J Connolly, Bin Zhu, Mark J Macielag, Michael R Brandt, Kristen Chevalier, Sui-Po Zhang, Timothy W. Lovenberg and Pascal Bonaventure
Journal of Pharmacology and Experimental Therapeutics December 9, 2019, jpet.119.262139; DOI: https://doi.org/10.1124/jpet.119.262139
Research ArticleDrug Discovery and Translational Medicine
Pharmacologic characterization of JNJ-42226314, [1-(4-fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a reversible, selective and potent monoacylglycerol lipase inhibitor
Ryan M Wyatt, Ian Fraser, Natalie Welty, Brian Lord, Michelle Wennerholm, Steven W Sutton, Michael K Ameriks, Christine Dugovic, Sujin Yun, Allison White, Leslie Nguyen, Tatiana Koudriakova, Gaochao Tian, Javier Suarez, Lawrence Szewczuk, William Bonnette, Kay Ahn, Brahma Ghosh, Christopher M Flores, Peter J Connolly, Bin Zhu, Mark J Macielag, Michael R Brandt, Kristen Chevalier, Sui-Po Zhang, Timothy W. Lovenberg and Pascal Bonaventure
Journal of Pharmacology and Experimental Therapeutics December 9, 2019, jpet.119.262139; DOI: https://doi.org/10.1124/jpet.119.262139
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