Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Pharmacology and Experimental Therapeutics
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Journal of Pharmacology and Experimental Therapeutics

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit jpet on Facebook
  • Follow jpet on Twitter
  • Follow jpet on LinkedIn
Research ArticleSpecial Section Articles

The Opioid Crisis and the Future of Addiction and Pain Therapeutics

Nathan P. Coussens, G. Sitta Sittampalam, Samantha G. Jonson, Matthew D. Hall, Heather E. Gorby, Amir P. Tamiz, Owen B. McManus, Christian C. Felder and Kurt Rasmussen
Journal of Pharmacology and Experimental Therapeutics September 3, 2019, jpet.119.259408; DOI: https://doi.org/10.1124/jpet.119.259408
Nathan P. Coussens
1 National Institutes of Health;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nathan P. Coussens
G. Sitta Sittampalam
1 National Institutes of Health;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Samantha G. Jonson
1 National Institutes of Health;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthew D. Hall
1 National Institutes of Health;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Heather E. Gorby
2 Orvos Communications, LLC.;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amir P. Tamiz
1 National Institutes of Health;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Owen B. McManus
3 Q-State Biosciences;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian C. Felder
4 Karuna Therapeutics
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kurt Rasmussen
1 National Institutes of Health;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading

Abstract

Opioid misuse and addiction are a public health crisis resulting in debilitation, deaths, and significant social and economic impact. Curbing this crisis requires collaboration among academic, government, and industrial partners towards the development of effective non-addictive pain medications, interventions for opioid overdose, and addiction treatments. A two-day meeting, The Opioid Crisis and the Future of Addiction and Pain Therapeutics: Opportunities, Tools, and Technologies Symposium, was held at the National Institutes of Health to address these concerns and to chart a collaborative path forward. The meeting was supported by the NIH HEAL (Helping to End Addiction Long-termSM) Initiative, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid crisis. The event was unique in bringing together two research disciplines, addiction and pain, to create a forum for cross-communication and collaboration. The output from the symposium will be considered by the HEAL Initiative; this article summarizes the scientific presentations and key takeaways. Improved understanding of the etiology of acute and chronic pain will enable the discovery of novel targets and regulatable pain circuits for safe and effective therapeutics, as well as relevant biomarkers to ensure adequate testing in clinical trials. Applications of improved technologies including reagents, assays, model systems, and validated probe compounds will likely increase the delivery of testable hypotheses and therapeutics to enable better health outcomes for patients. The symposium goals were achieved by increasing interdisciplinary collaboration to accelerate solutions for this pressing public health challenge and provide a framework for focused efforts within the research community.

SIGNIFICANCE STATEMENT This article summarizes key messages and discussions resulting from a two-day symposium focused on challenges and opportunities in developing addiction- and pain-related medications. Speakers and attendees came from 40 US states and 15 countries bringing perspectives from academia, industry, government, and healthcare by researchers, clinicians, regulatory experts, and patient advocates.

  • animal models
  • antinociception
  • drug targeting
  • drug tolerance/dependence
  • nociception
  • opioid receptors
  • opioids
  • The American Society for Pharmacology and Experimental Therapeutics
Next
Back to top

In this issue

Journal of Pharmacology and Experimental Therapeutics: 384 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 384, Issue 2
1 Feb 2023
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
The Opioid Crisis and the Future of Addiction and Pain Therapeutics
(Your Name) has forwarded a page to you from Journal of Pharmacology and Experimental Therapeutics
(Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleSpecial Section Articles

The Opioid Crisis and the Future of Addiction and Pain Therapeutics

Nathan P. Coussens, G. Sitta Sittampalam, Samantha G. Jonson, Matthew D. Hall, Heather E. Gorby, Amir P. Tamiz, Owen B. McManus, Christian C. Felder and Kurt Rasmussen
Journal of Pharmacology and Experimental Therapeutics September 3, 2019, jpet.119.259408; DOI: https://doi.org/10.1124/jpet.119.259408

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleSpecial Section Articles

The Opioid Crisis and the Future of Addiction and Pain Therapeutics

Nathan P. Coussens, G. Sitta Sittampalam, Samantha G. Jonson, Matthew D. Hall, Heather E. Gorby, Amir P. Tamiz, Owen B. McManus, Christian C. Felder and Kurt Rasmussen
Journal of Pharmacology and Experimental Therapeutics September 3, 2019, jpet.119.259408; DOI: https://doi.org/10.1124/jpet.119.259408
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About JPET
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0103 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics