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Research ArticleMetabolism, Transport, and Pharmacogenomics

Pharmacokinetic assessment of cooperative efflux of the multi-targeted kinase inhibitor ponatinib across the blood-brain barrier

Janice K Laramy, Minjee Kim, Karen E. Parrish, Jann N. Sarkaria and William F. Elmquist
Journal of Pharmacology and Experimental Therapeutics February 12, 2018, jpet.117.246116; DOI: https://doi.org/10.1124/jpet.117.246116

Article Information

jpet.117.246116
DOI 
https://doi.org/10.1124/jpet.117.246116
PubMed 
29440450
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Published online February 12, 2018.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Janice K Laramy1,
  2. Minjee Kim1,
  3. Karen E. Parrish1,
  4. Jann N. Sarkaria2, and
  5. William F. Elmquist1,*
  1. 1 University of Minnesota;
  2. 2 Mayo Clinic
  1. ↵*Address correspondence to: elmqu011{at}umn.edu

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Research ArticleMetabolism, Transport, and Pharmacogenomics

Pharmacokinetic assessment of cooperative efflux of the multi-targeted kinase inhibitor ponatinib across the blood-brain barrier

Janice K Laramy, Minjee Kim, Karen E. Parrish, Jann N. Sarkaria and William F. Elmquist
Journal of Pharmacology and Experimental Therapeutics February 12, 2018, jpet.117.246116; DOI: https://doi.org/10.1124/jpet.117.246116
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