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Research ArticleNeuropharmacology

AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice

Jenny L Wiley, Julie A Marusich, Timothy W Lefever, Kateland R Antonazzo, Michael T Wallgren, Ricardo A Cortes, Purvi R Patel, Megan Grabenauer, Katherine N Moore and Brian F Thomas
Journal of Pharmacology and Experimental Therapeutics June 23, 2015, jpet.115.225326; DOI: https://doi.org/10.1124/jpet.115.225326
Jenny L Wiley
RTI International
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Julie A Marusich
RTI International
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Timothy W Lefever
RTI International
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Kateland R Antonazzo
RTI International
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Michael T Wallgren
RTI International
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Ricardo A Cortes
RTI International
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Purvi R Patel
RTI International
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Megan Grabenauer
RTI International
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Katherine N Moore
RTI International
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Brian F Thomas
RTI International
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Abstract

Diversion of synthetic cannabinoids for abuse began in the early 2000s. Despite legislation banning compounds currently on the drug market, illicit manufacturers continue to release new compounds for recreational use. This study examined new synthetic cannabinoids AB-CHMINACA, AB-PINACA, and FUBIMINA, with the hypothesis that these compounds, like those before them, would be highly susceptible to abuse. Cannabinoids were examined in vitro for binding and activation of CB1 receptors, and in vivo for pharmacological effects in mice and in Δ9-THC discrimination. AB-CHMINACA, AB-PINACA and FUBIMINA bound to and activated CB1 and CB2 receptors, and produced locomotor suppression, antinociception, hypothermia, and catalepsy. Further, these compounds, along with JWH-018, CP47,497, and WIN55,212-2, substituted for Δ9-THC in Δ9-THC discrimination. Rank order of potency correlated with CB1 receptor binding affinity, and all three compounds were full agonists in [35S]GTPγS binding, as compared to the partial agonist Δ9-THC. Indeed, AB-CHMINACA and AB-PINACA exhibited higher efficacy than most known full agonists of the CB1 receptor. Preliminary analysis of urinary metabolites of the compounds revealed the expected hydroxylation. AB-PINACA and AB-CHMINACA are of potential interest as research tools due to their unique chemical structures and high CB1 receptor efficacies. Further studies on these chemicals is likely to include research on understanding cannabinoid receptors and other components of the endocannabinoid system that underlie the abuse of synthetic cannabinoids.

  • animal models
  • behavioral pharmacology
  • cannabinoid receptors
  • cannabinoids
  • The American Society for Pharmacology and Experimental Therapeutics
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Journal of Pharmacology and Experimental Therapeutics: 384 (2)
Journal of Pharmacology and Experimental Therapeutics
Vol. 384, Issue 2
1 Feb 2023
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Research ArticleNeuropharmacology

AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice

Jenny L Wiley, Julie A Marusich, Timothy W Lefever, Kateland R Antonazzo, Michael T Wallgren, Ricardo A Cortes, Purvi R Patel, Megan Grabenauer, Katherine N Moore and Brian F Thomas
Journal of Pharmacology and Experimental Therapeutics June 23, 2015, jpet.115.225326; DOI: https://doi.org/10.1124/jpet.115.225326

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Research ArticleNeuropharmacology

AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in Mice

Jenny L Wiley, Julie A Marusich, Timothy W Lefever, Kateland R Antonazzo, Michael T Wallgren, Ricardo A Cortes, Purvi R Patel, Megan Grabenauer, Katherine N Moore and Brian F Thomas
Journal of Pharmacology and Experimental Therapeutics June 23, 2015, jpet.115.225326; DOI: https://doi.org/10.1124/jpet.115.225326
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