Research ArticleDrug Discovery and Translational Medicine
Pharmacology of basimglurant (RO4917523, RG7090), a unique mGlu5 negative allosteric modulator in clinical development for depression
Lothar Lindemann, Richard H Porter, Sebastian H Scharf, Basil Kuennecke, Andreas Bruns, Markus von Kienlin, Anthony C Harrison, Axel Paehler, Christoph Funk, Andreas Gloge, Manfred Schneider, Neil J Parrott, Liudmila Polonchuk, Urs Niederhauser, Stephen R Morairty, Thomas S Kilduff, Eric Vieira, Sabine Kolczewski, Juergen Wichmann, Thomas Hartung, Michael Honer, Edilio Borroni, Jean-Luc Moreau, Eric Prinssen, Will Spooren, Joseph G Wettstein and Georg Jaeschke
Journal of Pharmacology and Experimental Therapeutics February 9, 2015, jpet.114.222463; DOI: https://doi.org/10.1124/jpet.114.222463
Lothar Lindemann
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Richard H Porter
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Sebastian H Scharf
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Basil Kuennecke
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Andreas Bruns
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Markus von Kienlin
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Anthony C Harrison
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Axel Paehler
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Christoph Funk
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Andreas Gloge
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Manfred Schneider
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Neil J Parrott
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Liudmila Polonchuk
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Urs Niederhauser
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Stephen R Morairty
2 Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California 94025, USA
Thomas S Kilduff
2 Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California 94025, USA
Eric Vieira
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Sabine Kolczewski
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Juergen Wichmann
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Thomas Hartung
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Michael Honer
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Edilio Borroni
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Jean-Luc Moreau
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Eric Prinssen
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Will Spooren
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Joseph G Wettstein
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
Georg Jaeschke
1 F. Hoffmann-La Roche AG, pRED, Innovation Center Basel, Switzerland;
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In this issue
Research ArticleDrug Discovery and Translational Medicine
Pharmacology of basimglurant (RO4917523, RG7090), a unique mGlu5 negative allosteric modulator in clinical development for depression
Lothar Lindemann, Richard H Porter, Sebastian H Scharf, Basil Kuennecke, Andreas Bruns, Markus von Kienlin, Anthony C Harrison, Axel Paehler, Christoph Funk, Andreas Gloge, Manfred Schneider, Neil J Parrott, Liudmila Polonchuk, Urs Niederhauser, Stephen R Morairty, Thomas S Kilduff, Eric Vieira, Sabine Kolczewski, Juergen Wichmann, Thomas Hartung, Michael Honer, Edilio Borroni, Jean-Luc Moreau, Eric Prinssen, Will Spooren, Joseph G Wettstein and Georg Jaeschke
Journal of Pharmacology and Experimental Therapeutics February 9, 2015, jpet.114.222463; DOI: https://doi.org/10.1124/jpet.114.222463
Research ArticleDrug Discovery and Translational Medicine
Pharmacology of basimglurant (RO4917523, RG7090), a unique mGlu5 negative allosteric modulator in clinical development for depression
Lothar Lindemann, Richard H Porter, Sebastian H Scharf, Basil Kuennecke, Andreas Bruns, Markus von Kienlin, Anthony C Harrison, Axel Paehler, Christoph Funk, Andreas Gloge, Manfred Schneider, Neil J Parrott, Liudmila Polonchuk, Urs Niederhauser, Stephen R Morairty, Thomas S Kilduff, Eric Vieira, Sabine Kolczewski, Juergen Wichmann, Thomas Hartung, Michael Honer, Edilio Borroni, Jean-Luc Moreau, Eric Prinssen, Will Spooren, Joseph G Wettstein and Georg Jaeschke
Journal of Pharmacology and Experimental Therapeutics February 9, 2015, jpet.114.222463; DOI: https://doi.org/10.1124/jpet.114.222463
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