Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of OATP1B1 substrates using a mechanistic net-effect model

Manthena Varma; Yi-an Bi; Emi Kimoto; Jian Lin

doi:10.1124/jpet.114.215970

Research ArticleMetabolism, Transport, and Pharmacogenomics

Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of OATP1B1 substrates using a mechanistic net-effect model

Manthena Varma, Yi-an Bi, Emi Kimoto and Jian Lin

Journal of Pharmacology and Experimental Therapeutics August 8, 2014, jpet.114.215970; DOI: https://doi.org/10.1124/jpet.114.215970

Manthena Varma

Pfizer

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Yi-an Bi

Pfizer

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Emi Kimoto

Pfizer

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Jian Lin

Pfizer

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Journal of Pharmacology and Experimental Therapeutics

Vol. 382, Issue 1

1 Jul 2022

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Research ArticleMetabolism, Transport, and Pharmacogenomics

Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of OATP1B1 substrates using a mechanistic net-effect model

Manthena Varma, Yi-an Bi, Emi Kimoto and Jian Lin

Journal of Pharmacology and Experimental Therapeutics August 8, 2014, jpet.114.215970; DOI: https://doi.org/10.1124/jpet.114.215970

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Research ArticleMetabolism, Transport, and Pharmacogenomics

Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of OATP1B1 substrates using a mechanistic net-effect model

Manthena Varma, Yi-an Bi, Emi Kimoto and Jian Lin

Journal of Pharmacology and Experimental Therapeutics August 8, 2014, jpet.114.215970; DOI: https://doi.org/10.1124/jpet.114.215970

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Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of OATP1B1 substrates using a mechanistic net-effect model

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Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of OATP1B1 substrates using a mechanistic net-effect model

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Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of OATP1B1 substrates using a mechanistic net-effect model

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