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Supplemental Figure 1: Chemical structure of JNJ-18038683... Supplemental Figure 2: Effect of oral administration (A) and intraperitoneal (B) of JNJ-18038683 on 5-CT-induced hypothermia in rats. Supplemental Table 1: In vitro selectivity profile of JNJ-18038683. Supplemental Table 2: Summary of secondary efficacy results from the MDD study at week 7... Supplemental Table 3: HAMD-17 total score - change from baseline to end point (LOCF)...
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Notice of Revision
Correction to "Translational Evaluation of JNJ-18038683, a 5-HT7 Receptor Antagonist, on REM Sleep and in Major Depressive Disorder"
The Fast Forward manuscript version of the above article published on May 8, 2012 [Bonaventure P, Dugovic C, Kramer M, De Boer P, Singh J, Wilson S, Bertelsen K, Di J, Shelton J, Aluisio L, Dvorak L, Fraser I, Lord B, Nepomuceno D, Ahnaou A, Drinkenburg W, Chai W, Dvorak C, Carruthers N, Sands S, and Lovenberg T, J Pharmacol Exp Ther, doi:10.1124/jpet.112.193995] was found to contain errors.
For all of the preclinical studies and for the two polysomnograph studies carried out in healthy subjects, JNJ-18038683 was compared to citalopram. For the clinical trial in patients suffering from major depressive disorder, escitalopram was used as an active comparator. Escitalopram was used as an active comparator in order to set the clinical bar as high as possible.
While preparing the manuscript for submission, the authors accidentally converted "escitalopram" into "citalopram," and the mistake was not caught during the review process.
In addition, "statistically significant" was not deleted from the abstract of the revised version of the manuscript. The post hoc analysis was statistically significant on the HAMD-17 scale but not on the MADRS scale. Since the MADRS scale was used as a primary end point, "statistically significant" should have been deleted from the abstract.
A corrected version of the manuscript was submitted to the Editor, reviewed, and posted on May 23, 2012. The differences between the two versions of the manuscript should have been noted at that time for readers. The authors and ASPET regret these errors and apologize for any confusion and inconvenience this may have caused.