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- Data Supplement - Supplemental Figure 1: Area under the time-response curves shown in Figures 7 and 8 was calculated using GraphPad Prism as the net area of the positive (above 0) and negative (below 0) peaks. Data were analyzed with one way ANOVA followed by Bonferroni's post test to determine differences between the treatments. In the absence of BK pre-treatment (Vehicle), U50488 did not alter the response to PGE2. Following BK pre-treatment, the dose-response to U50488, between 0.01 and 10 μg, appeared as an inverted U shape. The effect of U50488 (1 μg) was blocked by the KOR antagonists, nor-BNI (10 μg) or 5'-GNTI (2 μg). Data represent the mean +/- SEM for 6 animals per group.