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A p97/valosin-containing protein inhibitor drug CB-5083 has a potent but reversible off-target effect on phosphodiesterase-6
Henri Leinonen, Cheng Cheng, Marja Pitkänen, Christopher L. Sander, Jianye Zhang, Sama Saeid, Teemu Turunen, Alyaa Shmara, Lan Weiss, Lac Ta, Timothy Ton, Ari Koskelainen, Jesse D Vargas, Virginia Kimonis and Krzysztof Palczewski

Journal of Pharmacology and Experimental Therapeutics April 30, 2021, JPET-AR-2020-000486; DOI: https://doi.org/10.1124/jpet.120.000486
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Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2′-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide–Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6
Thomas A. Zanardi, Birgit Korbmacher, Laura Boone, Jeffrey A. Engelhardt, Yanfeng Wang, Sebastien Burel, Bobby Prill, Mariam Aghajan, Shuling Guo and Scott P. Henry

Journal of Pharmacology and Experimental Therapeutics April 2021, 377 (1) 51-63; DOI: https://doi.org/10.1124/jpet.120.000222
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A Preclinical Safety Study of Thyroid Hormone Instilled into the Lungs of Healthy Rats—an Investigational Therapy for ARDS
Craig M. Flory, Beverly J. Norris, Nicole A. Larson, Lia G. Coicou, Brenda L. Koniar, Margaret A. Mysz, Timothy P. Rich, David H. Ingbar and Robert J. Schumacher

Journal of Pharmacology and Experimental Therapeutics January 2021, 376 (1) 74-83; DOI: https://doi.org/10.1124/jpet.120.000060
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Untargeted Metabolomics Reveals Anaerobic Glycolysis as a Novel Target of the Hepatotoxic Antidepressant Nefazodone
Evelin Krajnc, Michele Visentin, Zhibo Gai, Bruno Stieger, Sophia L. Samodelov, Stephanie Häusler and Gerd A. Kullak-Ublick

Journal of Pharmacology and Experimental Therapeutics November 2020, 375 (2) 239-246; DOI: https://doi.org/10.1124/jpet.120.000120
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Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes
Malcolm Lane, D’Arice Carter, Joseph D. Pescrille, Yasco Aracava, William P. Fawcett, G. William Basinger, Edna F.R. Pereira and Edson X. Albuquerque

Journal of Pharmacology and Experimental Therapeutics October 2020, 375 (1) 115-126; DOI: https://doi.org/10.1124/jpet.120.265843
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Chronic Ethanol Feeding in Mice Decreases Expression of Genes for Major Structural Bone Proteins in a Nox4-Independent Manner
Kim B. Pedersen, Michelle L. Osborn, Alex C. Robertson, Ashlee E. Williams, James Watt, Alexandra Denys, Katrin Schröder and Martin J. Ronis

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 337-346; DOI: https://doi.org/10.1124/jpet.119.264374
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Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor
Wenqi Cui, Xunan Shen, Emre Agbas, Brandon Tompkins, Hadley Cameron-Carter and Jeff L. Staudinger

Journal of Pharmacology and Experimental Therapeutics June 2020, 373 (3) 370-380; DOI: https://doi.org/10.1124/jpet.119.264762
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Arsenite-Induced Mitochondrial Superoxide Formation: Time and Concentration Requirements for the Effects of the Metalloid on the Endoplasmic Reticulum and Mitochondria
Andrea Guidarelli, Liana Cerioni, Mara Fiorani, Alessia Catalani and Orazio Cantoni

Journal of Pharmacology and Experimental Therapeutics April 2020, 373 (1) 62-71; DOI: https://doi.org/10.1124/jpet.119.262469
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3,4-Dihydroxyphenylacetaldehyde Is More Efficient than Dopamine in Oligomerizing and Quinonizing α-Synuclein
Yunden Jinsmaa, Risa Isonaka, Yehonatan Sharabi and David S. Goldstein

Journal of Pharmacology and Experimental Therapeutics February 2020, 372 (2) 157-165; DOI: https://doi.org/10.1124/jpet.119.262246
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Functional Interaction between Pregnane X Receptor and Yes-Associated Protein in Xenobiotic-Dependent Liver Hypertrophy and Drug Metabolism
Taiki Abe, Ryota Shizu, Takamitsu Sasaki, Yuki Shimizu, Takuomi Hosaka, Susumu Kodama, Atsushi Matsuzawa and Kouichi Yoshinari

Journal of Pharmacology and Experimental Therapeutics December 2019, 371 (3) 590-601; DOI: https://doi.org/10.1124/jpet.119.258632

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