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Siponimod As a Novel Inhibitor of Retinal Angiogenesis: In Vitro and In Vivo Evidence of Therapeutic Efficacy
Rasha A. Alshaikh, Rania Gamal Eldin Zaki, Rania A. Salah El Din, Katie B. Ryan and Christian Waeber

Journal of Pharmacology and Experimental Therapeutics August 2023, 386 (2) 224-241; DOI: https://doi.org/10.1124/jpet.122.001529
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Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis
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Journal of Pharmacology and Experimental Therapeutics August 2023, 386 (2) 242-258; DOI: https://doi.org/10.1124/jpet.123.001639
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Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation
Alison Cutts, Sultan Chowdhury, Laszlo G Ratkay, Maryanne Eyers, Clint Young, Rostam Namdari, Jay A Cadieux, Navjot Chahal, Michael Grimwood, Zaihui Zhang, Sophia Lin, Ian Tietjen, Zhiwei Xie, Lee Robinette, Luis Sojo, Matthew Waldbrook, Michael Hayden, Tarek Mansour, Simon Pimstone, Y. Paul Goldberg, Michael Webb and Charles J. Cohen

Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 4-14; DOI: https://doi.org/10.1124/jpet.122.001435
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Pharmacological Profile of Difamilast, a Novel Selective Phosphodiesterase 4 Inhibitor, for Topical Treatment of Atopic Dermatitis
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Journal of Pharmacology and Experimental Therapeutics July 2023, 386 (1) 45-55; DOI: https://doi.org/10.1124/jpet.123.001609
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In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Molecule ent-Verticilide
Daniel J. Blackwell, Abigail N. Smith, Tri Do, Aaron Gochman, Jeffrey Schmeckpeper, Corey R. Hopkins, Wendell S. Akers, Jeffrey N. Johnston and Bjorn C. Knollmann

Journal of Pharmacology and Experimental Therapeutics June 2023, 385 (3) 205-213; DOI: https://doi.org/10.1124/jpet.122.001455
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TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy
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Journal of Pharmacology and Experimental Therapeutics June 2023, 385 (3) 193-204; DOI: https://doi.org/10.1124/jpet.122.001449
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Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage
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Journal of Pharmacology and Experimental Therapeutics May 2023, 385 (2) 106-116; DOI: https://doi.org/10.1124/jpet.122.001431
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Heroin- and Fentanyl-Induced Respiratory Depression in a Rat Plethysmography Model: Potency, Tolerance, and Sex Differences
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The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease
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Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 382-392; DOI: https://doi.org/10.1124/jpet.122.001423
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The Effects of Dual GLP-1/Glucagon Receptor Agonists with Different Receptor Selectivity in Mouse Models of Obesity and Nonalcoholic Steatohepatitis
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Journal of Pharmacology and Experimental Therapeutics March 2023, 384 (3) 406-416; DOI: https://doi.org/10.1124/jpet.122.001440

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